Evidence map›Paper›PMID 34857621›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Dosimetry for Radiopharmaceutical Therapy: Current Practices and Commercial Resources.

Jacek Capala, Stephen A Graves, Aaron Scott, George Sgouros, Sara St James, Pat Zanzonico, Brian E Zimmerman

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06395402 (177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry), which is not on this map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06395402 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry

TypeinterventionalSponsorUniversity of IowaRan2024 to 2029Enrolled120ConditionsNeuroendocrine Tumors, Neuroendocrine Tumor Grade 1, Neuroendocrine Tumor Grade 2ArmsLutetium Lu 177 dotatate therapy
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 68 citations in OpenAlex.

  1. Tumor and Organ Dose Estimates fromJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  2. Dosimetry of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  3. Dosimetry-Driven Personalization of Radiopharmaceutical Therapies: Evidence and Opportunities.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  4. Article
  5. Article
  6. Dosimetry inJournal of clinical medicine · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. OpenDose3D: A Free, Open-Source Clinical Dosimetry Software for Patient-Specific Dosimetry.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Jacek CapalaNational Cancer Institute, Bethesda, Maryland.
Stephen A GravesUniversity of Iowa, Iowa City, Iowa.
Aaron ScottJohns Hopkins University, Baltimore, Maryland.
George SgourosJohns Hopkins University, Baltimore, Maryland.
Sara St JamesUniversity of California, San Francisco, California.
Pat ZanzonicoMemorial Sloan Kettering Cancer Center, New York, New York; and zanzonip@mskcc.org.
Brian E ZimmermanNational Institute of Standards and Technology, Gaithersburg, Maryland.
Johns Hopkins University · USMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USNational Institute of Standards and Technology · USUniversity of California, San Francisco · USUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the ongoing dramatic growth of radiopharmaceutical therapy, research and development in internal radiation dosimetry continue to advance both at academic medical centers and in industry. The basic paradigm for patient-specific dosimetry includes administration of a pretreatment tracer activity of the therapeutic radiopharmaceutical; measurement of its time-dependent biodistribution; definition of the pertinent anatomy; integration of the measured time-activity data to derive source-region time-integrated activities; calculation of the tumor, organ-at-risk, and/or whole-body absorbed doses; and prescription of the therapeutic administered activity. This paper provides an overview of the state of the art of patient-specific dosimetry for radiopharmaceutical therapy, including current methods and commercially available software and other resources.

Indexed as

RadiometryRadiopharmaceuticalsHumansSoftwareRadiopharmaceuticalsdosimetryradiopharmaceutical therapySPECT

Identifiers

PMID34857621
PMCPMC12079727
OpenAlexW3217160467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.