Evidence map›Paper›PMID 34857530›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2022

Perfluorinated Carboxylic Acids with Increasing Carbon Chain Lengths Upregulate Amino Acid Transporters and Modulate Compensatory Response of Xenobiotic Transporters in HepaRG Cells.

Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman, Julia Yue Cui

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of PFAS on human liver transporters: implications for health outcomes.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joe Jongpyo LimDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Youjun SuhDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Elaine M FaustmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
Julia Yue CuiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington juliacui@uw.edu.
University of Washington · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
Developmental PBDE exposure, gut microbiome, and diabetesR01ES030197 · NIEHS · UNIVERSITY OF WASHINGTON · PI Julia Yue Cui, Haiwei Gu · 2019 to 2026
$5.0M
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?R01ES031098 · NIEHS · UNIVERSITY OF IOWA · PI CUI, JULIA YUE, LEHMLER, HANS-JOACHIM · 2020 to 2024
$3.1M
Epigenetic Regulation of Drug Metabolism by Developmental Exposure to PBDEsR01ES025708 · NIEHS · UNIVERSITY OF WASHINGTON · PI CUI, JULIA YUE · 2015 to 2019
$1.7M
Developmental Regulation of Drug Metabolism by Targeting the Gut MicrobiomeR01GM111381 · NIGMS · UNIVERSITY OF WASHINGTON · PI CUI, JULIA YUE · 2014 to 2018
$1.5M
NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES025708NIEHS NIH HHS R01 ES030197NIEHS NIH HHS R01 ES031098NIEHS NIH HHS T32 ES007032NIGMS NIH HHS R01 GM111381
6 · The paper itself

Abstract

Perfluorinated carboxylic acids (PFCAs) are widespread environmental pollutants for which human exposure has been documented. PFCAs at high doses are known to regulate xenobiotic transporters partly through peroxisome proliferator-activated receptor alpha (PPAR

Indexed as

Carboxylic AcidsEnvironmental PollutantsAmino AcidsAmino Acid Transport SystemsCarbonDimethyl SulfoxideHumansOximesPPAR alphaThiazolesXenobioticsAmino AcidsAmino Acid Transport SystemsCarbonCarboxylic AcidsDimethyl SulfoxideEnvironmental PollutantsOximesPPAR alphaThiazolesXenobiotics

Identifiers

PMID34857530
PMCPMC9513853
OpenAlexW3215269020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.