Evidence map›Paper›PMID 34857389›Full record

ArticleInternational dental journal2022

Oral Health, Diabetes, and Inflammation: Effects of Oral Hygiene Behaviour.

Huabin Luo, Bei Wu, Angela R Kamer, Samrachana Adhikari, Frank Sloan, Brenda L Plassman, Chenxin Tan, Xiang Qi, Mark D Schwartz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Edentulism, social mobility, and cognitive aging: a life course perspective.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Huabin LuoBrody School of Medicine, East Carolina University, Greenville, North Carolina, USA. Electronic address: luoh@ecu.edu.
Bei WuRory Meyers College of Nursing, New York University, New York, New York, USA.
Angela R KamerCollege of Dentistry, New York University, New York, New York, USA.
Samrachana AdhikariGrossman School of Medicine, New York University, New York, New York. USA.
Frank SloanSanford School of Public Policy, Duke University, Durham, North Carolina, USA.
Brenda L PlassmanSchool of Medicine, Duke University, Durham, North Carolina, USA.
Chenxin TanRory Meyers College of Nursing, New York University, New York, New York, USA.
Xiang QiRory Meyers College of Nursing, New York University, New York, New York, USA.
Mark D SchwartzGrossman School of Medicine, New York University, New York, New York. USA.
New York University · USDuke University · USEast Carolina University · US

Funding

Diversity supplement to the U01 project-Care partner assisted intervention to improve oral health for person with mild dementiaU01DE027512 · NIDCR · NEW YORK UNIVERSITY · PI ANDERSON, RUTH A, PLASSMAN, BRENDA L · 2018 to 2023
$3.9M
Pathways from co-occurrence of poor oral health and diabetes to Alzheimer's disease and related dementia (ADRD) and mortalityR56AG067619 · NIA · NEW YORK UNIVERSITY · PI LUO, HUABIN, WU, BEI · 2020 to 2020
$519k
NIA NIH HHS R56 AG067619NIDCR NIH HHS U01 DE027512
6 · The paper itself

Abstract

introductionThe aim of this research was to assess the association between inflammation and oral health and diabetes, as well as the mediating role of oral hygiene practice in this association.

methodsData were from the 2009-2010 National Health and Nutrition Examination Survey. The analytical sample consisted of 2,191 respondents aged 50 and older. Poor oral health was clinically defined by significant tooth loss (STL) and periodontal disease (PD). Diabetes mellitus (DM) was determined by glycemic levels. The outcome variable was serum C-reactive protein (CRP) level, dichotomised as ≥1 mg/dL (elevated CRP) vs <1 mg/dL (not elevated CRP). Two path models, one using STL and DM as the independent variable, the other using PD and DM as the independent variable, were estimated to assess the direct effects of having poor oral health and DM on elevated CRP and the mediating effects of dental flossing.

resultsIn path model 1, individuals having both STL and DM (adjusted odds ratio [AOR], 1.92; 95% confidence interval [CI], 1.30-2.82) or having STL alone (AOR, 2.30; 95% CI, 1.68-3.15) were more likely to have elevated CRP than those with neither STL nor DM; dental flossing (AOR, 0.92, 95% CI, 0.88-0.96) was associated with lower risk of elevated CRP. In path model 2, no significant association was found between having both PD and DM and elevated CRP; dental flossing (AOR, 0.91; 95% CI:, 0.86-0.94) was associated with lower risk of elevated CRP.

conclusionsFindings from this study highlight the importance of improving oral health and oral hygiene practice to mitigate inflammation. Further research is needed to assess the longer-term effects of reducing inflammation.

Indexed as

Diabetes MellitusPeriodontal DiseasesTooth LossAgedC-Reactive ProteinHumansInflammationMiddle AgedNutrition SurveysOral HealthOral HygieneC-Reactive ProteinDiabetesInflammationPeriodontal diseaseTooth loss

Identifiers

PMID34857389
PMCPMC9259379
OpenAlexW3217136506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.