Evidence map›Paper›PMID 34857226›Full record

Trial reportClinical nutrition ESPEN2021

Omega-3 supplementation during unilateral resistance exercise training in older women: A within subject and double-blind placebo-controlled trial.

M S Brook, Usu Din, J Tarum, A Selby, J Quinlan, J J Bass, N Gharahdaghi, C Boereboom, H Abdulla, M V Franchi and 7 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition ESPEN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. The effect of fish oil supplementation on resistance training-induced adaptations.Journal of the International Society of Sports Nutrition · 2023
    Trial
  8. Review
  9. The Role of Omega-3 Polyunsaturated Fatty Acids on Sarcopenia and Aging Muscle.International journal of environmental research and public health · 2026
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

M S BrookMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK; School of Life Sciences, University of Nottingham, Nottingham, UK.
Usu DinMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
J TarumSchool of Health Sciences, Örebro University, Örebro, Sweden.
A SelbyMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
J QuinlanSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK; National Institute for Health Research, Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
J J BassMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
N GharahdaghiMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
C BoereboomMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
H AbdullaMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
M V FranchiDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
M V NariciDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
B E PhillipsMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
J W WilliamsMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
F KadiSchool of Health Sciences, Örebro University, Örebro, Sweden.
D J WilkinsonMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
P J AthertonMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK.
K SmithMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Clinical, Metabolic and Molecular Physiology, School of Medicine, University of Nottingham, Derby, UK. Electronic address: ken.smith@nottingham.ac.uk.
University of Nottingham · GBVersus Arthritis · GBÖrebro University · SEUniversity of Padua · ITUniversity of Birmingham · GB

Funding

Medical Research Council MR/P021220/1Medical Research Council MR/R502364/1The Dunhill Medical Trust R364/1112
6 · The paper itself

Abstract

BACKGROUND &

aimsThe skeletal muscle anabolic effects of n-3 polyunsaturated fatty acids (n-3 PUFA) appear favoured towards women; a property that could be exploited in older women who typically exhibit poor muscle growth responses to resistance exercise training (RET). Here we sought to generate novel insights into the efficacy and mechanisms of n-3 PUFA alongside short-term RET in older women.

methodsWe recruited 16 healthy older women (Placebo n = 8 (PLA): 67±1y, n-3 PUFA n = 8: 64±1y) to a randomised double-blind placebo-controlled trial (n-3 PUFA; 3680 mg/day versus PLA) of 6 weeks fully-supervised progressive unilateral RET (i.e. 6 × 8 reps, 75% 1-RM, 3/wk

resultsRET increased 1-RM equally in the trained leg of both groups (+23 ± 5% n-3 PUFA vs. +25 ± 5% PLA (both P < 0.01)) with no significant increase in maximum voluntary contraction (MVC) (+10 ± 6% n-3 PUFA vs. +13 ± 5% PLA). Only the n-3 PUFA group increased TFFM (3774 ± 158 g to 3961 ± 151 g n-3 PUFA (P < 0.05) vs. 3406 ± 201 g to 3561 ± 170 PLA) and type II fibre CSA (3097 ± 339 μm

conclusionn3-PUFA enhanced RET gains in muscle mass through type II fibre hypertrophy, with data suggesting a role for MPS rather than via SC recruitment. As such, the present study adds to a literature base illustrating the apparent enhancement of muscle hypertrophy with RET in older women fed adjuvant n3-PUFA.

Indexed as

Resistance TrainingAgedDietary SupplementsExerciseFemaleHumansMiddle AgedMuscle ProteinsMuscle, SkeletalMuscle ProteinsAgingOmega 3Protein synthesisSkeletal muscleWomen

Identifiers

PMID34857226
PMCPMC8629763
OpenAlexW3204661359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.