ArticleJournal of the American College of Cardiology2021
Preeclampsia Predicts Risk of Hospitalization for Heart Failure With Preserved Ejection Fraction.
Article in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Risk Prediction Models and Novel Prognostic Factors for Heart Failure with Preserved Ejection Fraction: A Systematic and Comprehensive Review.Current pharmaceutical design · 2023Pooled it
- From bump to pump: extracellular matrix remodeling, dynamics, and biomechanics in the maternal heart.American journal of physiology. Heart and circulatory physiology · 2026Review
- Adverse Pregnancy Outcomes and Prevalent Cardiovascular Disease Among an Urban Cohort in Haiti.JACC. Advances · 2026Article
- Cardiac Implications of Preeclampsia: A Review.Journal of personalized medicine · 2026Review
- Association of hypertension disorders of pregnancy and left ventricular remodeling after 15 years follow-up: findings from the Bogalusa Heart Study.Journal of hypertension · 2026Article
- Ceramide as a Biomarker for HFpEF in Women: Menopause, Aging, and Pregnancy.International journal of molecular sciences · 2025Review
- The Impact of Preeclampsia and Gestational Diabetes on Future Maternal Cardiometabolic Health.Acta physiologica (Oxford, England) · 2025Review
- Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.American journal of preventive cardiology · 2025Article
- Long-Term Cardiovascular Risk and Maternal History of Pre-Eclampsia.Journal of clinical medicine · 2025Review
- Adverse Pregnancy Outcomes and Long-Term Risk of Heart Failure in Women: National Cohort and Co-Sibling Study.JACC. Heart failure · 2025Article
- Hypertensive pregnancy disorder, an under-recognized women specific risk factor for heart failure?European journal of heart failure · 2025Review
- Endothelial METAP1: Tipping the Angiogenic Scales in Postpartum Preeclampsia.Circulation research · 2025Article
- The effect of guideline-directed medicine on patients with new-onset heart failure following acute myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- Pathophysiology of Preeclampsia-Induced Vascular Dysfunction and Implications for Subclinical Myocardial Damage and Heart Failure.JACC. Advances · 2024Review
- Pregnancy, Reproductive Factors, and Female Heart Failure Risk and Outcomes.Current heart failure reports · 2024Review
- Coronary Microvascular Function Following Severe Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Coronary Microvascular Function Following Severe Preeclampsia.medRxiv : the preprint server for health sciences · 2024Article
- The Impact of Congestive Heart Failure on Outcomes in Patients Hospitalized With Preeclampsia.Cureus · 2024Article
- A disease of her own? Unique features of heart failure in women.Climacteric : the journal of the International Menopause Society · 2024Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPreeclampsia is associated with increased risk of future heart failure (HF), but the relationship between preeclampsia and HF subtypes are not well-established.
objectivesThe objective of this analysis was to identify the risk of HF with preserved ejection fraction (HFpEF) following a delivery complicated by preeclampsia/eclampsia.
methodsA retrospective cohort study using the New York and Florida state Healthcare Cost and Utilization Project State Inpatient Databases identified delivery hospitalizations between 2006 and 2014 for women with and without preeclampsia/eclampsia. The authors identified women admitted for HF after discharge from index delivery hospitalization until September 30, 2015, using International Classification of Diseases-9th Revision-Clinical Modification diagnosis codes. Patients were followed from discharge to the first instance of primary outcome (HFpEF hospitalization), death, or end of study period. Secondary outcomes included hospitalization for any HF and HF with reduced ejection fraction, separately. The association between preeclampsia/eclampsia and HFpEF was analyzed using Cox proportional hazards models.
resultsThere were 2,532,515 women included in the study: 2,404,486 without and 128,029 with preeclampsia/eclampsia. HFpEF hospitalization was significantly more likely among women with preeclampsia/eclampsia, after adjusting for baseline hypertension and other covariates (aHR: 2.09; 95% CI: 1.80-2.44). Median time to onset of HFpEF was 32.2 months (interquartile range: 0.3-65.0 months), and median age at HFpEF onset was 34.0 years (interquartile range: 29.0-39.0 years). Both traditional (hypertension, diabetes mellitus) and sociodemographic (Black race, rurality, low income) risk factors were also associated with HFpEF and secondary outcomes.
conclusionsPreeclampsia/eclampsia is an independent risk factor for future hospitalizations for HFpEF.
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