ArticleGut microbes
Multivariate associative patterns between the gut microbiota and large-scale brain network connectivity.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effects of oral probiotic intervention on brain structure and function in human adults: a systematic review.NPJ biofilms and microbiomes · 2026Pooled it
- Gut-brain axis and neuroplasticity in health and disease: a systematic review.La Radiologia medica · 2025Pooled it
- A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease.Molecular psychiatry · 2023Pooled it
- A gut feeling: Exploring the effects of probiotics on risk-taking behavior using TMS.iScience · 2026Article
- Review
- Beyond the 'second brain': the gut microbiota as a constitutive co-constructor of embodied cognitive network.Frontiers in neuroscience · 2026Review
- Xiaoyaosan modulates gut-brain metabolic pathways and brain microstructure in depression: a multi-omics insight.Chinese medicine · 2025Article
- Intestinal short-chain fatty acid turnover is not associated with resting state functional connectivity in mesolimbic dopaminergic network in healthy adults.Neuroimage. Reports · 2025Article
- Gut microbiota: emerging biomarkers and potential therapeutics for premature ovarian failure.Frontiers in microbiology · 2025Review
- Article
- Stress-Resilience Impacts Psychological Wellbeing: Evidence from Brain-Gut Microbiome Interactions.Nature. Mental health · 2024Article
- Receptor-Independent Therapies for Forensic Detainees with Schizophrenia-Dementia Comorbidity.International journal of molecular sciences · 2023Article
- Hybrid Techniques of Facial Feature Image Analysis for Early Detection of Autism Spectrum Disorder Based on Combined CNN Features.Diagnostics (Basel, Switzerland) · 2023Article
- COVID-19 Patients with Early Gastrointestinal Symptoms Show Persistent Deficits in Specific Attention Subdomains.Journal of clinical medicine · 2023Article
- Influence of gut microbiota on resilience and its possible mechanisms.International journal of biological sciences · 2023Review
- A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children.Frontiers in neuroscience · 2023Review
- Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior.BMC medicine · 2022Article
- The effects of probiotics on risk and time preferences.Scientific reports · 2022Article
- Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency.Frontiers in psychiatry · 2022Article
- The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury.International journal of biological sciences · 2022Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on the gut-brain axis has accelerated substantially over the course of the last years. Many reviews have outlined the important implications of understanding the relation of the gut microbiota with human brain function and behavior. One substantial drawback in integrating gut microbiome and brain data is the lack of integrative multivariate approaches that enable capturing variance in both modalities simultaneously. To address this issue, we applied a linked independent component analysis (LICA) to microbiota and brain connectivity data.We analyzed data from 58 healthy females (mean age = 21.5 years). Magnetic Resonance Imaging data were acquired using resting state functional imaging data. The assessment of gut microbial composition from feces was based on sequencing of the V4 16S rRNA gene region. We used the LICA model to simultaneously factorize the subjects' large-scale brain networks and microbiome relative abundance data into 10 independent components of spatial and abundance variation.LICA decomposition resulted in four components with non-marginal contribution of the microbiota data. The default mode network featured strongly in three components, whereas the two-lateralized fronto-parietal attention networks contributed to one component. The executive-control (with the default mode) network was associated to another component. We found that the abundance of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.