ArticleHypertension (Dallas, Tex. : 1979)2022
Mechanisms of Flow-Mediated Dilation of Pial Collaterals and the Effect of Hypertension.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.Journal of the American Heart Association · 2024Pooled it
- Article
- Cerebral small vessel disease does not impair leptomeningeal collateral supply in large-vessel occlusion - Results from quantitative collateral mapping with MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Feasibility of high-resolution flow-mediated dilation using a 24-MHz probe to assess endothelial dysfunction: comparison of hypertensive and normotensive groups.Ultrasonography (Seoul, Korea) · 2025Article
- Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- History of pre-eclampsia negatively impacts stroke severity postpartum in rats.Neuroprotection (Chichester, England) · 2025Article
- Dilated lenticulostriate artery on whole-brain vessel wall imaging differentiates pathogenesis and predicts clinical outcomes in single subcortical infarction.European radiology · 2025Article
- Chronic hypertension alters the relationship between collateral blood flow cortical cerebral blood flow, and brain tissue oxygenation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation.Frontiers in neurology · 2024Article
- Elastin-like polypeptide delivery of anti-inflammatory peptides to the brain following ischemic stroke.bioRxiv : the preprint server for biology · 2023Article
- Therapeutic Induction of Collateral Flow.Translational stroke research · 2023Review
- Plasticity of cerebral microvascular structure and mechanics during hypertension and following recovery of arterial pressure.American journal of physiology. Heart and circulatory physiology · 2022Article
- The role of nitric oxide in flow-induced and myogenic responses in 1A, 2A, and 3A branches of the porcine middle cerebral artery.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Leptomeningeal anastomoses are small distal anastomotic vessels also known as pial collaterals in the brain. These vessels redirect blood flow during an occlusion and are important for stroke treatment and outcome. Pial collaterals have unique hemodynamic forces and experience significantly increased luminal flow and shear stress after the onset of ischemic stroke. However, there is limited knowledge of how pial collaterals respond to flow and shear stress, and whether this response is altered in chronic hypertension. Using an in vitro system, pial collaterals from normotensive and hypertensive rats (n=6-8/group) were isolated and luminal flow was induced with intravascular pressure maintained at 40 mm Hg. Collateral lumen diameter was measured following each flow rate in the absence or presence of pharmacological inhibitors and activators. Collaterals from male and female Wistar rats dilated similarly to increased flow (2 µL/minute: 58.4±18.7% versus 67.9±7.4%;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.