ArticleNeuroImage2022
White matter association tracts underlying language and theory of mind: An investigation of 809 brains from the Human Connectome Project.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- White matter predicts tDCS antidepressant effects in a sham-controlled clinical trial study.European archives of psychiatry and clinical neuroscience · 2023Trial
- Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cerebellar pathway diffusion MRI measures are linked to core autism symptoms in early adolescents aged 9 to 11 years.Brain structure & function · 2026Article
- Neighborhood opportunity, white matter, and cognition in a large pediatric neuroimaging study.Translational psychiatry · 2026Article
- Study of sex differences in the whole brain white matter using diffusion MRI tractography and suprathreshold fiber cluster statistics.NeuroImage. Clinical · 2026Article
- A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography.Human brain mapping · 2025Article
- Study of Sex Differences in the Whole Brain White Matter Using Diffusion MRI Tractography and Suprathreshold Fiber Cluster Statistics.bioRxiv : the preprint server for biology · 2025Article
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- The superficial white matter in language processing: Broca's area connections are bilaterally associated with individual performance in children and adults.bioRxiv : the preprint server for biology · 2025Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- The Shape of the Brain's Connections Is Predictive of Cognitive Performance: An Explainable Machine Learning Study.Human brain mapping · 2025Review
- Prediction of Verbal Abilities From Brain Connectivity Data Across the Lifespan Using a Machine Learning Approach.Human brain mapping · 2025Article
- TractCloud-FOV: Deep Learning-Based Robust Tractography Parcellation in Diffusion MRI With Incomplete Field of View.Human brain mapping · 2025Article
- Consistent cerebellar pathway-cognition associations across pre-adolescents & young adults: a diffusion MRI study of 9000+ participants.bioRxiv : the preprint server for biology · 2025Article
- Fiber microstructure quantile (FMQ) regression: A novel statistical approach for analyzing white matter bundles from periphery to core.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- From Motion to Emotion: Visual Pathways and Potential Interconnections.Journal of cognitive neuroscience · 2024Review
- Neuroanatomical changes observed over the course of a human pregnancy.Nature neuroscience · 2024Article
- Posttraumatic survivor guilt is associated with white matter microstructure alterations.Journal of affective disorders · 2024Article
- Deep multimodal saliency parcellation of cerebellar pathways: Linking microstructure and individual function through explainable multitask learning.Human brain mapping · 2024Article
- A diffusion MRI tractography atlas for concurrent white matter mapping across Eastern and Western populations.Scientific data · 2024Article
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11 authors.
Funding
Abstract
Language and theory of mind (ToM) are the cognitive capacities that allow for the successful interpretation and expression of meaning. While functional MRI investigations are able to consistently localize language and ToM to specific cortical regions, diffusion MRI investigations point to an inconsistent and sometimes overlapping set of white matter tracts associated with these two cognitive domains. To further examine the white matter tracts that may underlie these domains, we use a two-tensor tractography method to investigate the white matter microstructure of 809 participants from the Human Connectome Project. 20 association white matter tracts (10 in each hemisphere) are uniquely identified by leveraging a neuroanatomist-curated automated white matter tract atlas. The fractional anisotropy (FA), mean diffusivity (MD), and number of streamlines (NoS) are measured for each white matter tract. Performance on neuropsychological assessments of semantic memory (NIH Toolbox Picture Vocabulary Test, TPVT) and emotion perception (Penn Emotion Recognition Test, PERT) are used to measure critical subcomponents of the language and ToM networks, respectively. Regression models are constructed to examine how structural measurements of left and right white matter tracts influence performance across these two assessments. We find that semantic memory performance is influenced by the number of streamlines of the left superior longitudinal fasciculus III (SLF-III), and emotion perception performance is influenced by the number of streamlines of the right SLF-III. Additionally, we find that performance on both semantic memory & emotion perception is influenced by the FA of the left arcuate fasciculus (AF). The results point to multiple, overlapping white matter tracts that underlie the cognitive domains of language and ToM. Results are discussed in terms of hemispheric dominance and concordance with prior investigations.
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