Evidence map›Paper›PMID 34856321›Full record

ArticleNeurochemistry international2022

The formation of small aggregates contributes to the neurotoxic effects of tau

Sana Afreen, Adriana Ferreira

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sana AfreenDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Adriana FerreiraDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: a-ferreira@northwestern.edu.
Northwestern University · US

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MESULAM, MAREK-MARSEL M · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SANDRA WEINTRAUB · 2021 to 2026
$26.3M
Mechanisms Underlying Tau45-230-Induced Neuronal DegenerationR01NS090993 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FERREIRA, ADRIANA B. · 2015 to 2019
$1.7M
nvestigating the role of neuroinflammation in Limbic-predominant age related TDP43 encephalopathyK08AG065463 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FLANAGAN, MARGARET E · 2020 to 2024
$816k
NIA NIH HHS K08 AG065463NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072977NINDS NIH HHS R01 NS090993
6 · The paper itself

Abstract

Intracellular deposits of hyperphosphorylated tau are commonly detected in tauopathies. Furthermore, these aggregates seem to play an important role in the pathobiology of these diseases. In the present study, we determined whether the recently identified neurotoxic tau

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrainFemaleHippocampusHumansMaleNeuronsNeurotoxicity SyndromesPhosphorylationTauopathiestau Proteinstau ProteinsAlzheimer's diseaseClathrin-mediated endocytosisNeuronal degenerationTau(45-230) aggregatestau(45-230) internalization

Identifiers

PMID34856321
PMCPMC8712401
OpenAlexW3215587223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.