ReviewNeuropharmacology2022
At the heart of the interoception network: Influence of the parasubthalamic nucleus on autonomic functions and motivated behaviors.
Review in Neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Enhanced substance P-NK1R signaling in the parabrachial-parasubthalamic pathway promotes hyperalgesia and affective aversion in neuropathic pain.Acta pharmacologica Sinica · 2026Article
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety.Molecular psychiatry · 2026Article
- Associations between thyroid hormones and biochemical metabolism in major depressive disorder patients with and without comorbid eating disorders.Eating and weight disorders : EWD · 2026Article
- GABAergic Inhibition from the Nucleus Tractus Solitarius to Ventrolateral Medulla Phox2b Neurons Modulates Central Respiratory Chemoreflex and Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence.bioRxiv : the preprint server for biology · 2026Article
- Whole-Brain Monosynaptic Inputs to Parasubthalamic Calretinin Neurons in Mice.Molecular neurobiology · 2025Article
- Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A noncanonical parasubthalamic nucleus-to-extended amygdala circuit converts chronic social stress into anxiety.The Journal of clinical investigation · 2025Article
- Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice.Cell reports · 2025Article
- A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Candidate Key Proteins of Tinnitus in the Auditory and Motor Systems of the Thalamus.International journal of molecular sciences · 2025Article
- Tachykinin-1-expressing parasubthalamic nucleus neurons are necessary for odorant-induced appetite suppression.Physiology & behavior · 2025Article
- The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking.Molecular psychiatry · 2025Article
- Sex-Dimorphic Kidney-Brain Connectivity Map of Mice.Neuroscience bulletin · 2024Article
- Neural circuits regulation of satiation.Appetite · 2024Review
- Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024Article
- A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety.Nature neuroscience · 2024Article
- Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.Nature communications · 2023Article
- Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.Nature communications · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The parasubthalamic nucleus (PSTN), a small nucleus located on the lateral edge of the posterior hypothalamus, has emerged in recent years as a highly interconnected node within the network of brain regions sensing and regulating autonomic function and homeostatic needs. Furthermore, the strong integration of the PSTN with extended amygdala circuits makes it ideally positioned to serve as an interface between interoception and emotions. While PSTN neurons are mostly glutamatergic, some of them also express neuropeptides that have been associated with stress-related affective and motivational dysfunction, including substance P, corticotropin-releasing factor, and pituitary adenylate-cyclase activating polypeptide. PSTN neurons respond to food ingestion and anorectic signals, as well as to arousing and distressing stimuli. Functional manipulation of defined pathways demonstrated that the PSTN serves as a central hub in multiple physiologically relevant networks and is notably implicated in appetite suppression, conditioned taste aversion, place avoidance, impulsive action, and fear-induced thermoregulation. We also discuss the putative role of the PSTN in interoceptive dysfunction and negative urgency. This review aims to synthesize the burgeoning preclinical literature dedicated to the PSTN and to stimulate interest in further investigating its influence on physiology and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.