Evidence map›Paper›PMID 34856129›Full record

ArticleNeuron2021

Unraveling the mysteries of MYT1L: From reprogramming factor to multifaceted regulator of neuronal differentiation.

Aniket Bhattacharya, M Chiara Manzini

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aniket BhattacharyaChild Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
M Chiara ManziniChild Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA. Electronic address: chiara.manzini@rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Neuron, Chen et al. (2021) generated a mouse model for haploinsufficiency of MYT1L. MYT1L is widely used in neuronal reprogramming, and de novo mutations have been linked to a neurodevelopmental syndrome. Extensive characterization in this study better delineates MYT1L's role in transcriptional regulation and neuronal differentiation.

Indexed as

Nerve Tissue ProteinsTranscription FactorsAnimalsGene Expression RegulationHaploinsufficiencyMiceNeuronsNerve Tissue ProteinsTranscription Factorsautismgene transcriptionintellectual disabilityMyt1lneuronal development

Identifiers

PMID34856129
OpenAlexW3217623699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.