Evidence map›Paper›PMID 34856101›Full record

ArticleJournal of the American Chemical Society2021

Enzyme-Like Hydroxylation of Aliphatic C-H Bonds From an Isolable Co-Oxo Complex.

McKenna K Goetz, Joseph E Schneider, Alexander S Filatov, Kate A Jesse, John S Anderson

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Beyond the Oxo-Wall: Synthesis and Reactivity of a Six-Coordinate Formally CoAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. First Evidence for Ozonido-TMC Complexes of Iron and Cobalt.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. 10-Fold Increase in Hydrogen Atom Transfer Reactivity for a Series ofJournal of the American Chemical Society · 2025
    Article
  9. Isolation and Crystallographic Characterization of an Octavalent CoJournal of the American Chemical Society · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Anaerobic Hydroxylation of C(spJournal of the American Chemical Society · 2023
    Article
  14. Synthesis and reactivity of a tris(carbene) zinc chloride complex.Dalton transactions (Cambridge, England : 2003) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

McKenna K GoetzDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0001-8352-7630
Joseph E SchneiderDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.
Alexander S FilatovDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-8378-1994
Kate A JesseDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-3527-4007
John S AndersonDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-0730-3018
University of Chicago · US

Funding

Equipment Supplement: Distal Anion Stabilization of Biologically Relevant Oxo IntermediatesR35GM133470 · NIGMS · UNIVERSITY OF CHICAGO · PI ANDERSON, JOHN STUART · 2019 to 2023
$2.1M
NIGMS NIH HHS R35 GM133470
6 · The paper itself

Abstract

The selective hydroxylation of aliphatic C-H bonds remains a challenging but broadly useful transformation. Nature has evolved systems that excel at this reaction, exemplified by cytochrome P450 enzymes, which use an iron-oxo intermediate to activate aliphatic C-H bonds with

Indexed as

AdamantaneAlcoholsCatalysisCobaltCoordination ComplexesDensity Functional TheoryHydroxylationLigandsModels, ChemicalOxidantsOxidation-ReductionAdamantaneAlcoholsCobaltCoordination ComplexesLigandsOxidants

Identifiers

PMID34856101
PMCPMC8919985
OpenAlexW3216648373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.