ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022
Deep medullary veins are associated with widespread brain structural abnormalities.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Deep medullary veins score is associated with idiopathic normal pressure hydrocephalus in patients with arteriolosclerotic cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- Worse visibility of deep medullary veins is associated with larger lateral ventricles but not with cortical thickness.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026Article
- Deep medullar veins: predictors of clinical progression in Alzheimer's disease.Quantitative imaging in medicine and surgery · 2026Article
- Higher basal ganglia perivascular space burden is associated with reduced deep medullary vein visibility via free water accumulation in sporadic cerebral small vessel disease.European journal of medical research · 2025Article
- Decreased Visibility of Deep Medullary Vein Associated with Cerebral Small Vessel Disease Burden through Increased Interstitial Fluid in White Matter.AJNR. American journal of neuroradiology · 2025Article
- Deep Medullary Vein Integrity and Relationships with Small Vessel Disease and Interstitial Diffusivity Measures in Patients with a Recent Small Subcortical Infarct.AJNR. American journal of neuroradiology · 2025Article
- Deep medullary veins: a promising neuroimaging marker for neurodegeneration in multiple sclerosis.Quantitative imaging in medicine and surgery · 2025Article
- Association of decreased visibility on deep medullary vein gray-matter volume mediated by increased extracellular fluid in the white matter of patients with cerebral small vessel disease.Quantitative imaging in medicine and surgery · 2025Article
- Deep medullary veins disruption in cerebral small vessel disease: links to AI-quantified lesions and cognitive decline.Frontiers in neurology · 2025Article
- Deep medullary vein damage correlates with small vessel disease in small vessel occlusion acute ischemic stroke.European radiology · 2024Article
- Dynamic Mechanism of Cerebral Venous Disruption: Longitudinal Evidence From a Community-Based Cohort.Journal of the American Heart Association · 2024Article
- Advancements in investigating the role of cerebral small vein loss in Alzheimer's disease-related pathological changes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Cerebral venous congestion alters brain metabolite profiles, impairing cognitive function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Potential role of plasma branched-chain amino acids in the differential diagnosis of acute cerebral venous thrombosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Risk factors of impaired employability after cerebral venous thrombosis.CNS neuroscience & therapeutics · 2023Article
- Deep Venous Remodeling in Unilateral Sturge-Weber Syndrome: Robust Hemispheric Differences and Clinical Correlates.Pediatric neurology · 2023Article
- Effect of dynamic cerebral autoregulation on the association between deep medullary vein changes and cerebral small vessel disease.Frontiers in physiology · 2023Article
- Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease.Quantitative imaging in medicine and surgery · 2023Article
- Brain Deep Medullary Veins on 7T MRI in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim is to investigate the association of cerebral deep medullary veins (DMVs) with white matter microstructural integrity and regional brain atrophy in MRI. In a community-based cohort of 979 participants (mean age 55.4 years), DMVs were identified on susceptibility-weighted imaging. Brain structural measurements including gray matter and hippocampus volumes, as well as diffusion tensor metrics, were evaluated. The mean (SD)number of DMVs was 19.0 (1.7). A fewer number of DMVs was related to lower fractional anisotropy and higher mean diffusivity in multiple voxels on the white matter skeleton (threshold-free cluster enhancement corrected p < 0.05, adjusted for age and sex). Also, fewer DMVs were significantly related to a lower gray matter fraction and a hippocampal fraction (0.10 and 0.11 per DMV, respectively; SE, 0.03 for both; p < 0.001 for both). A significant correlation between DMVs' reduction and cortical atrophy was observed in the bilateral occipital lobes, temporal lobes, hippocampus, and frontal lobes (p < 0.001, adjusted for age, sex, and total intracranial volume). Our results provided evidence that cerebral small venules disease play a role in brain parenchymal lesions and neurodegenerative processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.