SynthesisChronic respiratory disease
Diffusing capacity in chronic obstructive pulmonary disease assessment: A meta-analysis.
Synthesis in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Vascular-related proteomic signatures in COPD with suspected pulmonary hypertension as predictors of FEV₁ impairment.Respiratory research · 2026Article
- Clinical predictors of impaired pulmonary diffusing capacity in patients recovering from COVID-19: A secondary analysis of multicentre datasets.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
- The Predictive Value of the Combined FVC/DLCO Ratio and 1-Minute Heart Rate Recovery After Exercise in Stable Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension.International journal of general medicine · 2026Article
- Sleep, heart, and lungs: decoding the "triple trouble" phenotype in COPD - a cohort study.ERJ open research · 2025Article
- AI-Based HRCT Quantification in Connective Tissue Disease-Associated Interstitial Lung Disease.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Association between lung function and sleep disorder symptoms in a community-based multi-site case-finding study.Journal of sleep research · 2025Article
- Sex-specific associations between sleep apnoea and lung cancer risk in patients with COPD: a nationwide prospective cohort study.The Lancet regional health. Europe · 2025Article
- Prognostic Factors for Responders of Home-Based Pulmonary Rehabilitation-Secondary Analysis of a Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Reducing Hospital Readmissions in Chronic Obstructive Pulmonary Disease Patients: Current Treatments and Preventive Strategies.Medicina (Kaunas, Lithuania) · 2025Review
- A multidimensional grading system for ABPA treatment escalation within the first year: The HEID score.The World Allergy Organization journal · 2024Article
- Correlation between handgrip strength and air trapping in patients with stable chronic obstructive pulmonary disease.Journal of thoracic disease · 2024Article
- Pattern of Expression of Genes Involved in Systemic Inflammation and Glutathione Metabolism Reveals Exacerbation of COPD.Antioxidants (Basel, Switzerland) · 2024Article
- Risk factors of acute exacerbation and disease progression in young patients with COPD.BMJ open respiratory research · 2024Observational
- Pulmonary function trajectories in COVID-19 survivors with and without pre-existing respiratory disease.Scientific reports · 2024Article
- Unravelling the complex interplay of factors behind exercise limitations and physical inactivity in COPD.Breathe (Sheffield, England) · 2024Review
- Efficacy of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension patients with pulmonary comorbidity.International journal of cardiology. Heart & vasculature · 2024Article
- Pulmonary function testing in preoperative high-risk patients.Perioperative medicine (London, England) · 2024Article
- Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Predicting Lung Function Using Biomarkers in Alpha-1 Antitrypsin Deficiency.Biomedicines · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To achieve a multidimensional evaluation of chronic obstructive pulmonary disease (COPD) patients, the spirometry measures are supplemented by assessment of symptoms, risk of exacerbations, and CT imaging. However, the measurement of diffusing capacity of the lung for carbon monoxide (DLCO) is not included in most common used models of COPD assessment. Here, we conducted a meta-analysis to evaluate the role of DLCO in COPD assessment.The studies were identified by searching the terms "diffusing capacity" OR "diffusing capacity for carbon monoxide" or "DLCO" AND "COPD" AND "assessment" in Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Scopus, and Web of Science databases. The mean difference of DLCO % predict was assessed in COPD patient with different severity (according to GOLD stage and GOLD group), between COPD patients with or without with frequent exacerbation, between survivors and non-survivors, between emphysema dominant and non-emphysema dominant COPD patients, and between COPD patients with or without pulmonary hypertension.43 studies were included in the meta-analysis. DLCO % predicted was significantly lower in COPD patients with more severe airflow limitation (stage II/IV), more symptoms (group B/D), and high exacerbation risk (group C/D). Lower DLCO % predicted was also found in exacerbation patients and non-survivors. Low DLCO % predicted was related to emphysema dominant phenotype, and COPD patients with PH.The current meta-analysis suggested that DLCO % predicted might be an important measurement for COPD patients in terms of severity, exacerbation risk, mortality, emphysema domination, and presence of pulmonary hypertension. As diffusion capacity reflects pulmonary ventilation and perfusion at the same time, the predictive value of DLCO or DLCO combined with other criteria worth further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.