Evidence map›Paper›PMID 34855095›Full record

ArticleBulletin of experimental biology and medicine2021

Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Statins) Suppress Proliferation and Motility of Human CD4

N V Radyukhina, N Yu Ruleva, A Yu Filatova, T I Aref'eva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

N V RadyukhinaNational Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. nradukhina@mail.ru.
N Yu RulevaNational Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
A Yu FilatovaNational Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
T I Aref'evaNational Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) along with their blood lipid-lowering effect exhibit anti-inflammatory and immunomodulatory activity. We studied the effects of long-term (72-h or longer) exposure of human T lymphocytes in culture to atorvastatin and rosuvastatin (5-80 nM) on their functional activity. Treatment with statins inhibited PHA/IL-2-induced proliferation of CD4

Indexed as

AtorvastatinCD4-Positive T-LymphocytesCell ProliferationCells, CulturedChemotaxis, LeukocyteHumansHydroxymethylglutaryl-CoA Reductase InhibitorsReceptors, CCR4Receptors, CCR5Receptors, CXCR3Receptors, CXCR4Rosuvastatin CalciumSignal TransductionAtorvastatinCCR4 protein, humanCCR5 protein, humanCXCR3 protein, humanCXCR4 protein, humanHydroxymethylglutaryl-CoA Reductase InhibitorsReceptors, CCR4Receptors, CCR5Receptors, CXCR3Receptors, CXCR4Rosuvastatin Calciumapoptosisinhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins);migrationproliferationT lymphocytes

Identifiers

PMID34855095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.