Evidence map›Paper›PMID 34854982›Full record

Trial reportEuropean journal of applied physiology2022

Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients.

Patrick J Highton, Daniel S March, Darren R Churchward, Charlotte E Grantham, Hannah M L Young, Matthew P M Graham-Brown, Seila Estruel, Naomi Martin, Nigel J Brunskill, Alice C Smith and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patrick J HightonSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Daniel S MarchDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Darren R ChurchwardDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Charlotte E GranthamDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Hannah M L YoungJohn Walls Renal Unit, Leicester General Hospital, University Hospitals of Leicester, Leicester, UK.
Matthew P M Graham-BrownDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Seila EstruelDepartment of Physiological Sciences, University of Barcelona, Barcelona, Spain.
Naomi MartinLeicester School of Allied Health Sciences, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK.
Nigel J BrunskillDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Alice C SmithJohn Walls Renal Unit, Leicester General Hospital, University Hospitals of Leicester, Leicester, UK.
James O BurtonSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Nicolette C BishopSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. N.C.Bishop@lboro.ac.uk.ORCID http://orcid.org/0000-0001-6221-3907

Funding

NIHR CS-2013-13-014NIHR DRF-2016-09-015
6 · The paper itself

Abstract

purposePatients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact of regular, moderate-intensity IDC on circulating MPs and inflammatory markers in unit-based HD patients.

methodsPatients were cluster-randomised to intervention (n = 20, age: 51.4 ± 18.1 years, body mass: 77.6 ± 18.3 kg, mean ± SD) or no-exercise control (n = 20, 56.8 ± 14.0 years, 80.5 ± 26.5 kg). Intervention participants completed 30 min of moderate intensity (rating of perceived exertion [RPE] of 12-14) IDC, thrice weekly for 6 months. Pre-dialysis venous blood samples were obtained at 0, 3 and 6 months. Circulating MP phenotypes, cytokines, chemokine and MP TF expression were quantified using flow cytometry and cytometric bead array assays.

resultsDespite high exercise compliance (82%), no IDC-dependent effects were observed for any MP, cytokine or chemokine measure (p ≥ 0.051, η

conclusionSix months of regular, moderate-intensity IDC had no effect on MPs, cytokines or chemokines. This suggests that the exercise did not exacerbate thrombotic or inflammatory status, though further functional assays are required to confirm this.

trial registrationISRCTN1129707, prospectively registered on 05/03/2015.

Indexed as

BiomarkersCell-Derived MicroparticlesExercise TherapyHumansInflammationKidney Failure, ChronicMaleMiddle AgedPhenotypeRenal DialysisBiomarkersAerobic exerciseEnd-stage renal diseaseHaemodialysisInflammationIntradialytic cyclingMicroparticles

Identifiers

PMID34854982
PMCPMC8854296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.