ArticlePediatric surgery international2022
The need for early Kasai portoenterostomy: a Western Pediatric Surgery Research Consortium study.
Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Use of percutaneous cholecysto-cholangiogram in the evaluation of neonatal cholestasis.Journal of pediatric gastroenterology and nutrition · 2026Article
- National Analysis of Secular Trends and Racial Disparities in Age at Kasai Hepatoportoenterostomy for Infants with Biliary Atresia, 2005-2025.Annals of surgery · 2026Article
- Comparative outcomes of open and laparoscopic Kasai portoenterostomy for biliary Atresia patients progressing to liver transplantation: A Real-World cohort study.Surgery today · 2026Article
- MRI features of fetal type I congenital choledochal cyst and parameter measurement of hepatobiliary development.BMC medical imaging · 2026Article
- Differentiation of biliary atresia using a rapid point-of-care matrix metalloproteinase-7 assay: A multicenter diagnostic study.Hepatology communications · 2026Article
- Measuring MMP-7 levels in dried blood spots appears not feasible for newborn screening of biliary atresia.Hepatology communications · 2026Article
- Children With Biliary Atresia Have Substantial Morbidity in Early Childhood and a High Risk of Liver Transplantation.Birth defects research · 2026Article
- Early postnatal characteristics and differential diagnosis of choledochal cyst and cystic biliary atresia.World journal of gastroenterology · 2025Article
- Is performing the Kasai portoenterostomy in the neonatal period associated with a better prognosis? A single-center, retrospective cohort study from China.BMC pediatrics · 2025Article
- Efficacy of sodium bicarbonate Ringer's solution for perioperative fluid management in infants with biliary atresia: a prospective multicenter study.Pediatric surgery international · 2025Observational
- Primary antibiotic prophylaxis in biliary atresia did not demonstrate decreased infection rate: Multi-centre retrospective study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Infants with biliary atresia exhibit an altered amino acid profile in their newborn screening.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- Primary liver transplantationWorld journal of transplantation · 2024Article
- Role of cholinergic innervation in biliary remnants of patients with biliary atresia.Frontiers in pediatrics · 2023Article
- Selective enlargement of left lateral segment liver volume as a potential diagnostic predictor for biliary atresia.Pediatric surgery international · 2022Article
- Biliary atresia and congenital disorders of the extrahepatic bile ducts.World journal of gastrointestinal pharmacology and therapeutics · 2022Review
- Biliary Atresia in 2021: Epidemiology, Screening and Public Policy.Journal of clinical medicine · 2022Article
- Biliary Atresia: advances and challenges in early diagnosis and management.Jornal de pediatriaReview
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Authors and funding
23 authors at 9 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to investigate factors impacting transplant-free survival among infants with biliary atresia.
methodsA multi-institutional, retrospective cohort study was performed at nine tertiary-level children's hospitals in the United States. Infants who underwent Kasai portoenterostomy (KP) from January 2009 to May 2017 were identified. Clinical characteristics included age at time of KP, steroid use, surgical approach, liver pathology, and surgeon experience. Likelihood of transplant-free survival (TFS) was evaluated using logistic regression, adjusting for patient and surgeon-level factors. Secondary outcomes at 1 year included readmission, cholangitis, reoperation, mortality, and biliary clearance.
resultsOverall, 223 infants underwent KP, and 91 (40.8%) survived with their native liver. Mean age at surgery was 63.9 days (± 24.7 days). At 1 year, 78.5% experienced readmission, 56.9% developed cholangitis, 3.8% had a surgical revision, and 5 died. Biliary clearance at 3 months was achieved in 76.6%. Controlling for patient and surgeon-level factors, each additional day of age toward operation was associated with a 2% decrease in likelihood of TFS (OR 0.98, 95% CI 0.97-0.99).
conclusionEarlier surgical intervention by Kasai portoenterostomy at tertiary-level centers significantly increases likelihood for TFS. Policy-level interventions to facilitate early screening and surgical referral for infants with biliary atresia are warranted to improve outcomes.
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