Evidence map›Paper›PMID 34854919›Full record

ArticleJournal of cell science2022

Downregulation of collagen XI during late postnatal corneal development is followed by upregulation after injury.

Mei Sun, Devon Cogswell, Sheila Adams, Yasmin Ayoubi, Ambuj Kumar, Tea Reljic, Marcel Y Avila, Curtis E Margo, Edgar M Espana

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mei SunFrom the Cornea, External Disease Service, Department of Ophthalmology, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-0580-2814
Devon CogswellFrom the Cornea, External Disease Service, Department of Ophthalmology, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-1804-1463
Sheila AdamsFrom the Cornea, External Disease Service, Department of Ophthalmology, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-8580-8097
Yasmin AyoubiFrom the Cornea, External Disease Service, Department of Ophthalmology, University of South Florida, Tampa, FL 33612, USA.
Ambuj KumarResearch Methodology and Biostatistics Core, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-1260-6694
Tea ReljicResearch Methodology and Biostatistics Core, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Marcel Y AvilaDepartment of Ophthalmology, Universidad Nacional de Colombia, Bogota 111321, Colombia.ORCID 0000-0001-7734-8177
Curtis E MargoFrom the Cornea, External Disease Service, Department of Ophthalmology, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-1852-5369
Edgar M EspanaFrom the Cornea, External Disease Service, Department of Ophthalmology, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0001-8377-5212
University of South Florida · USUniversidad Nacional de Colombia · CO

Funding

Regulatory roles for collagen XII in establishment of corneal stromal structure and function and re-establishment after injuryR01EY029395 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI ESPANA, EDGAR MAURICIO · 2018 to 2022
$1.8M
NEI NIH HHS EY029395NEI NIH HHS R01 EY029395
6 · The paper itself

Abstract

Collagen XI plays a role in nucleating collagen fibrils and in controlling fibril diameter. The aim of this research was to elucidate the role that collagen XI plays in corneal fibrillogenesis during development and following injury. The temporal and spatial expression of collagen XI was evaluated in C57BL/6 wild-type mice. For wound-healing studies in adult mice, stromal injuries were created using techniques that avoid caustic chemicals. The temporal expression and spatial localization of collagen XI was studied following injury in a Col11a1 inducible knockout mouse model. We found that collagen XI expression occurs during early maturation and is upregulated after stromal injury in areas of regeneration and remodeling. Abnormal fibrillogenesis with new fibrils of heterogeneous size and shape occurs after injury in a decreased collagen XI matrix. In conclusion, collagen XI is expressed in the stroma during development and following injury in adults, and is a regulator of collagen fibrillogenesis in regenerating corneal tissue.

Indexed as

CollagenCorneaAnimalsDown-RegulationMiceMice, Inbred C57BLUp-RegulationCollagenCollagen XIFibroblastsRegenerationStromaWound

Identifiers

PMID34854919
PMCPMC8767274
OpenAlexW3214875435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.