Evidence map›Paper›PMID 34854577›Full record

ReviewKorean circulation journal2021

Biomaterials-based Approaches for Cardiac Regeneration.

Samhita Vasu, Justin Zhou, Jeffrey Chen, Peter V Johnston, Deok-Ho Kim

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Korean circulation journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Hydrogels for Cardiac Tissue Regeneration: Current and Future Developments.International journal of molecular sciences · 2025
    Review
  8. Use of Hydrogels in Regenerative Medicine: Focus on Mechanical Properties.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samhita VasuDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-8252-4980
Justin ZhouDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-2584-3592
Jeffrey ChenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-0311-8509
Peter V JohnstonDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-4258-6981
Deok-Ho KimDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-6989-6074
Johns Hopkins University · US

Funding

Korea Health Industry Development Institute HI19C0642
6 · The paper itself

Abstract

The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration.

Indexed as

Cardiovascular diseasesExtracellular vesiclesHeart failureTissue engineering

Identifiers

PMID34854577
PMCPMC8636758
OpenAlexW3206576331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.