ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Plasma p-tau
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In one paragraph
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Plasma Biomarkers for Alzheimer's Disease Across the Continuum: A Systematic Review of SIMOA-Based Studies.Cellular and molecular neurobiology · 2026Pooled it
- SIMOA-based analysis of plasma NFL levels in MCI and AD patients: a systematic review and meta-analysis.BMC neurology · 2023Pooled it
- Blood Biomarkers of Alzheimer Disease and Rates of Global and Domain-Specific Cognitive Decline.JAMA network open · 2026Article
- Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways.Acta neuropathologica communications · 2026Article
- Plasma extracellular vesicles and phosphorylated tau 181 as early biomarkers of cognitive impairment in Alzheimer's dementia.Alzheimer's research & therapy · 2026Article
- Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood-Based Biomarkers.Annals of neurology · 2025Article
- Distinctive volumetric associations between plasma p-tau181 and hippocampal formation structures across the Alzheimer's disease continuum.Journal of Alzheimer's disease : JAD · 2025Article
- Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.Sleep medicine · 2025Article
- Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers.Journal of Alzheimer's disease : JAD · 2025Article
- Does white matter and vascular injury from repetitive head impacts lead to a novel pattern on T2 FLAIR MRI? A hypothesis proposal and call for research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Closing the gap in dementia research by community-based cohort studies in the Chinese population.The Lancet regional health. Western Pacific · 2025Review
- Mood Symptoms are Associated With Cognitive Status, Brain Amyloid-Beta Deposition, and Plasma Biomarkers.Depression and anxiety · 2025Article
- Assessment of Wearable Device Adherence for Monitoring Physical Activity in Older Adults: Pilot Cohort Study.JMIR aging · 2024Article
- Plasma biomarkers for Alzheimer's and related dementias: A review and outlook for clinical neuropsychology.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Review
- Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease.Nature communications · 2024Article
- Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study.Acta neuropathologica · 2023Article
- Preanalytical stability of plasma/serum brain-derived tau.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Article
- Fluorescent Sensing Platforms for Detecting and Imaging the Biomarkers of Alzheimer's Disease.Biosensors · 2023Review
Corrections and comments
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Authors and funding
27 authors at 2 institutions in 3 countries.
Brandon FrankBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-0548-9074
Madeline AllyBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Bailee BrekkeBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Henrik ZetterbergDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Michael A SugarmanBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Nicholas J AshtonClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Thomas K KarikariClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Yorghos TripodisBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Brett MartinBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Joseph N PalmisanoBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Eric G SteinbergBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Irene SimkinaDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Katherine W TurkBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Andrew E BudsonBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Maureen K O'ConnorBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Rhoda AuBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Lee E GoldsteinBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Gyungah R JunDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Neil W KowallBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Thor D SteinBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Ann C McKeeBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Ronald KillianyBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Wei Qiao QiuBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Robert A SternBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Jesse MezBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Michael L AloscoBoston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Boston University · USSahlgrenska University Hospital · SE
Funding
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MProject-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MTBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ting Fang Alvin Ang · 2020 to 2026
$42.4MThe Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1MMetformin in Alzheimer's dementia Prevention (MAP)R01AG062624 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HANLEY, DANIEL F, LUCHSINGER, JOSE ALEJANDRO · 2019 to 2025
$37.8MNeuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1MAPOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4MRL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6MTox-AD: a new multi-institute tri-consortium data resource in the AD Knowledge PortalU24AG061340 · NIA · SAGE BIONETWORKS · PI Laura Michelle Heath, Susheel Varma · 2018 to 2026
$24.6MUltrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7MChronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0MMRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5MBLRD VA I01 BX002466BLRD VA I01 BX004613CSRD VA I01 CX001038CSRD VA IK2 CX002065NCATS NIH HHS UL1 TR001430NHLBI NIH HHS R01 HL141774NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG072978NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG029672NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG048927NIA NIH HHS R01 AG049810NIA NIH HHS R01 AG049899NIA NIH HHS R01 AG055337NIA NIH HHS R01 AG058822NIA NIH HHS R01 AG059011NIA NIH HHS R01 AG059424NIA NIH HHS R01 AG061028NIA NIH HHS R01 AG062109NIA NIH HHS R01 AG062348NIA NIH HHS R01 AG062624NIA NIH HHS R01 AG068398NIA NIH HHS R01 AG069453NIA NIH HHS R01 AG070883NIA NIH HHS R44 AG063635NIA NIH HHS R56 AG055337NIA NIH HHS R56 AG062109NIA NIH HHS R56 AG069130NIA NIH HHS RF1 AG054156NIA NIH HHS RF1 AG057768NIA NIH HHS RF1 AG057902NIA NIH HHS RF1 AG062109NIA NIH HHS RF1 AG075832NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG062602NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG068753NIA NIH HHS U24 AG061340NICHD NIH HHS R01 HD090191NINDS NIH HHS K23 NS102399NINDS NIH HHS U01 NS086659NINDS NIH HHS U01 NS093334NINDS NIH HHS U54 NS115266NIOSH CDC HHS R01 OH011511
Abstract
introductionWe examined the ability of plasma hyperphosphorylated tau (p-tau)
methodsPlasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables.
resultsPlasma p-tau DISCUSSION: These results support plasma p-tau
Indexed as
Alzheimer DiseaseCognitive DysfunctionBiomarkersHumansIntermediate Filamentstau ProteinsBiomarkersMAPT protein, humantau ProteinsAlzheimer's DiseaseNetwork analysisNeuropsychologyPlasma biomarkersP-tau
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.