Evidence map›Paper›PMID 34854548›Full record

ArticlePediatric blood & cancer2022

Trends in quality of care among children with sickle cell anemia.

Sarah L Reeves, Gary L Freed, Brian Madden, Meng Wu, Lauren Miller, Lindsay Cogan, David Anders, Susan E Creary, Julie McCormick, Kevin J Dombkowski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sarah L ReevesSusan B Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9145-0183
Gary L FreedSusan B Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Brian MaddenSusan B Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Meng WuNew York State Department of Health, Albany, New York, USA.
Lauren MillerNew York State Department of Health, Albany, New York, USA.
Lindsay CoganNew York State Department of Health, Albany, New York, USA.
David AndersNew York State Department of Health, Albany, New York, USA.
Susan E CrearyDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0002-4730-8139
Julie McCormickSusan B Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Kevin J DombkowskiSusan B Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · USNew York State Department of Health · USNationwide Children's Hospital · US

Funding

The Quality Measurement, Evaluation, Testing, Review and Implementation ConsortiuU18HS020516 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREED, GARY L. · 2011 to 2014
$6.9M
Q-METRIC Implementation and Quality ImprovementU18HS025292 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREED, GARY L. · 2016 to 2019
$2.6M
AHRQ HHS U18 HS020516AHRQ HHS U18 HS025292
6 · The paper itself

Abstract

introductionFor decades, it has been recommended that children with sickle cell anemia (SCA) receive antibiotic prophylaxis to prevent serious infections and undergo transcranial Doppler (TCD) screening to identify those at highest risk of overt stroke. We assessed recent temporal trends in antibiotic prophylaxis prescription fills and TCD screening among children with SCA using validated quality measures. PROCEDURE: Using validated claims-based definitions, we identified children with SCA who were enrolled in Michigan or New York State (NYS) Medicaid programs (2011-2018). Among recommended age groups, two outcomes were assessed yearly: (a) filling of ≥300 days of antibiotics, and (b) receipt of greater than or equal to one TCD. The proportion of children with each outcome was calculated by state. Temporal trends in each preventive service were assessed using generalized linear models.

resultsA total of 1784 children were eligible for antibiotic prophylaxis (Michigan: 384; NYS: 1400), contributing 3322 person-years. Annual rates of filling ≥300 days of antibiotics ranged from 16% to 22% and were similar by state. There was no change in rates of antibiotic filling over time in Michigan (p-value: .10), but there was a decrease in NYS (p-value: .02). A total of 3439 children with SCA were eligible for TCD screening (Michigan: 710; NYS: 2729), contributing 10,012 person-years. Annual rates of TCD screening ranged from 39% to 45%, were similar by state, and did not change over time (p-values >.05).

conclusionsMost children with SCA do not receive recommended antibiotic prophylaxis and/or TCD screening. New, sustainable, and coordinated interventions across preventive services are urgently needed.

Indexed as

Anemia, Sickle CellStrokeAnti-Bacterial AgentsChildHumansMass ScreeningUltrasonography, Doppler, TranscranialAnti-Bacterial Agentsepidemiologyquality of lifesickle cell anemia

Identifiers

PMID34854548
PMCPMC9367210
OpenAlexW3216908197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.