ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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35citing papers in PubMed, 1 pooled it
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature.Acta neuropathologica communications · 2022Pooled it
- Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody Functions.bioRxiv : the preprint server for biology · 2026Article
- Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Re-Purposing a Rho-Associated Coiled-Coil Kinase (ROCK) Inhibitor for Alzheimer's Disease.Journal of clinical medicine · 2026Article
- Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.Molecular neurodegeneration · 2026Article
- Neuron-specific epigenetic repression ofbioRxiv : the preprint server for biology · 2026Article
- Alterations in CSF Amyloid-β and Tau Biomarkers in Former College and Professional American Football Players: Findings from the DIAGNOSE CTE Research Project.Journal of neurotrauma · 2026Observational
- Procoagulant Extracellular Vesicles Increase Neuronal Tau expression, Metabolism and Processing Through Tissue Factor and Protease Activated Receptor 2.Cellular and molecular neurobiology · 2026Article
- Tau protein: Physiological functions and multifaceted roles in neurodegenerative and psychiatric disorders.Genomic psychiatry : advancing science from genes to society · 2025Article
- Genetic variation in TMEM106B alters microglial activation and cytokine responses in chronic traumatic encephalopathy.Acta neuropathologica · 2025Article
- Post-translational modifications regulating microglial inflammation in central nervous system disorders: a review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppAging cell · 2025Article
- Biomarker evidence of neurodegeneration in mid-life former rugby players.Brain : a journal of neurology · 2025Article
- Rhynchophylline alleviates cognitive deficits in multiple transgenic mouse models of Alzheimer's disease via modulating neuropathology and gut microbiota.Acta pharmacologica Sinica · 2025Article
- The Proteoform Landscape of Tau from the Human Brain.Journal of proteome research · 2025Article
- Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy.Molecular neurodegeneration · 2025Review
- The prevalence of chronic traumatic encephalopathy in a historical epilepsy post-mortem collection.Brain pathology (Zurich, Switzerland) · 2025Article
- Neuroinflammatory mechanisms may help identify candidate biomarkers in chronic traumatic encephalopathy (CTE).Free neuropathology · 2025Review
- Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts.Acta neuropathologica · 2024Article
- Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
20 authors at 1 institution in 1 country.
SpiroAnthony StathasBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-5939-4353
Victor E AlvarezBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Weiming XiaBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Raymond NicksBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Gaoyuan MengBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Sarah DaleyBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Morgan PothastBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Arsal ShahBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Hunter KelleyBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Camille EsnaultBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Robert McCormackBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Erin DixonBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Lucas FishbeinBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Jonathan D CherryBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Bertrand R HuberBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Yorghos TripodisBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Michael L AloscoBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Jesse MezBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Ann C McKeeBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Thor D SteinBoston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0001-6954-4477
Boston University · US
Funding
TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Thor Stein · 2020 to 2026
$42.4MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MNeuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1MRL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6MEPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MTraumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical SyndromesU54NS115266 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2019 to 2023
$10.3MCTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo ImagingU01NS086659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2014 to 2017
$6.1MAge-Associated Lipidomic Changes in Alzheimer's DiseaseRF1AG057768 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BLUSZTAJN, JAN KRZYSZTOF, STEIN, THOR · 2019 to 2021
$4.5MThe Contribution of Age-Related Taupahtoies to Alzheimer's Disease-SupplementR01AG062348 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CRARY, JOHN FONDA, DICKSON, DENNIS WILLIAM · 2018 to 2022
$4.5MTau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and NeuroinflammationRF1AG057902 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2017 to 2017
$4.1MEpigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive declineRF1AG054156 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, RYU, HOON · 2016 to 2018
$3.4MCSRD VA I01 CX001038NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001INIA NIH HHS K23 AG046377NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG072978NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG062348NIA NIH HHS R56 AG057768NIA NIH HHS RF1 AG054156NIA NIH HHS RF1 AG057768NIA NIH HHS RF1 AG057902NIA NIH HHS U19 AG068753NINDS NIH HHS K23 NS102399NINDS NIH HHS RF1 NS095252NINDS NIH HHS U01 NS086659NINDS NIH HHS U54 NS115266
Abstract
introductionChronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI) typically sustained by contact sport athletes. Post-translation modifications to tau in CTE have not been well delineated or compared to Alzheimer's disease (AD).
methodsWe measured phosphorylated tau epitopes within dorsolateral frontal cortex from post mortem brains with neither CTE nor AD (n = 108), CTE (n = 109), AD (n = 223), and both CTE and AD (n = 33).
resultsLevels of hyperphosphorylated tau (p-tau) DISCUSSION: In frontal cortex, p-tau
Indexed as
Alzheimer DiseaseChronic Traumatic EncephalopathyAmyloid beta-PeptidesHumansPhosphorylationtau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer's diseaseamyloid beta peptidesbrainchronic traumatic encephalopathyfootballhumansmalemicrotubule-associated proteinspathologystatistics and numerical datatauopathiestau proteins
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