Evidence map›Paper›PMID 34854376›Full record

ArticleeLife2021

Histone deacetylase 3 represses cholesterol efflux during CD4

Drew Wilfahrt, Rachael L Philips, Jyoti Lama, Monika Kizerwetter, Michael Jeremy Shapiro, Shaylene A McCue, Madeleine M Kennedy, Matthew J Rajcula, Hu Zeng, Virginia Smith Shapiro

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Sterols and immune mechanisms in asthma.The Journal of allergy and clinical immunology · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Drew WilfahrtDepartment of Immunology, Mayo Clinic, Rochester, United States.
Rachael L PhilipsDepartment of Immunology, Mayo Clinic, Rochester, United States.
Jyoti LamaDepartment of Immunology, Mayo Clinic, Rochester, United States.
Monika KizerwetterDepartment of Immunology, Mayo Clinic, Rochester, United States.ORCID 0000-0001-6084-7471
Michael Jeremy ShapiroDepartment of Immunology, Mayo Clinic, Rochester, United States.
Shaylene A McCueDepartment of Immunology, Mayo Clinic, Rochester, United States.
Madeleine M KennedyDepartment of Immunology, Mayo Clinic, Rochester, United States.
Matthew J RajculaDepartment of Immunology, Mayo Clinic, Rochester, United States.
Hu ZengDepartment of Immunology, Mayo Clinic, Rochester, United States.
Virginia Smith ShapiroDepartment of Immunology, Mayo Clinic, Rochester, United States.ORCID 0000-0001-9978-341X
WinnMed · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Regulation of gene expression by HDAC3R01AI150100 · NIAID · MAYO CLINIC ROCHESTER · PI SHAPIRO, VIRGINIA SMITH · 2020 to 2023
$2.1M
The role of Runx1 in the regulation of T cell anergyF31AI147438 · NIAID · MAYO CLINIC ROCHESTER · PI WILFAHRT, DREW N · 2020 to 2021
$71k
NCI NIH HHS P30 CA015083NIAID NIH HHS F31 AI147438NIAID NIH HHS R01 AI150100
6 · The paper itself

Abstract

After antigenic activation, quiescent naive CD4

Indexed as

AnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CD4-Positive T-LymphocytesCholesterolFemaleHistone Deacetylase 3Histone DeacetylasesMaleMiceMice, Mutant StrainsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolHistone Deacetylase 3Histone Deacetylasescholesterol regulationHDAC3immunologyinflammationmouseT cell activation

Identifiers

PMID34854376
PMCPMC8639145
OpenAlexW3216882758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.