Evidence map›Paper›PMID 34854276›Full record

ArticleHaematologica2022

A phase I study of the fully human, fragment crystallizable-engineered, anti-CD-33 monoclonal antibody BI 836858 in patients with previously-treated acute myeloid leukemia.

Sumithira Vasu, Jessica K Altman, Geoffrey L Uy, Martin S Tallman, Ivana Gojo, Gerard Lozanski, Ute Burkard, Annika Osswald, Pamela James, Björn Rüter and 1 more

Open access · goldAbstract readClinical Trial, Phase I
In one paragraph

Article in Haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Sumithira VasuDivision of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH.
Jessica K AltmanDivision of Hematology/Oncology, Northwestern University, Chicago, Illinois.
Geoffrey L UyWashington University School of Medicine, Siteman Cancer Center, St Louis, MO.
Martin S TallmanLeukemia Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY.
Ivana GojoThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.
Gerard LozanskiDepartment of Pathology, The Ohio State University, Columbus, OH.
Ute BurkardBoehringer Ingelheim Pharma GmbH and Co. KG, Biberach an der Riß.
Annika OsswaldBoehringer Ingelheim Pharma GmbH and Co. KG, Biberach an der Riß.
Pamela JamesBoehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT.
Björn RüterBoehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT.
William BlumDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA. william.g.blum@emory.edu.
Boehringer Ingelheim (India) · INBoehringer Ingelheim (United States) · USThe Ohio State University · USMemorial Sloan Kettering Cancer Center · USNorthwestern University · USSidney Kimmel Comprehensive Cancer Center · USWashington University in St. Louis · USWinship Cancer Institute

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, MonoclonalLeukemia, Myeloid, AcuteAntibodies, Monoclonal, HumanizedHumansImmunoglobulin Fc FragmentsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBI 836858Immunoglobulin Fc Fragments

Identifiers

PMID34854276
PMCPMC8883544
OpenAlexW3217773428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.