Evidence map›Paper›PMID 34854264›Full record

ArticleJournal of veterinary science2021

Formulation of a rational dosage regimen of ceftiofur hydrochloride oily suspension by pharmacokinetic-pharmacodynamic (PK-PD) model for treatment of swine

Wanhe Luo, Dehai Wang, Hua Qin, Dongmei Chen, Yuanhu Pan, Wei Qu, Lingli Huang, Shuyu Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Kill Rate and Evaluation ofFrontiers in veterinary science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wanhe Luo *National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China.ORCID https://orcid.org/0000-0002-5170-1670
Dehai Wang *College of Animal Science and Technology-College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.ORCID https://orcid.org/0000-0001-7444-741X
Hua QinBeijing TEAM Junwei Healthcare Technology Development Co., Ltd., Beijing 102600, China.ORCID https://orcid.org/0000-0001-6018-273X
Dongmei ChenNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China.ORCID https://orcid.org/0000-0003-0284-0671
Yuanhu PanNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China.ORCID https://orcid.org/0000-0003-3763-9169
Wei QuNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China.ORCID https://orcid.org/0000-0001-5035-7700
Lingli HuangNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China.ORCID https://orcid.org/0000-0002-8780-1534
Shuyu XieNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China.ORCID https://orcid.org/0000-0003-0381-2509
Huazhong Agricultural University · CNChina Institute of Veterinary Drug Control · CNAnnoroad Gene Technology (China) · CN

Funding

National Key Research and Development Program of China 2016YFD0501309
6 · The paper itself

Abstract

backgroundOur previously prepared ceftiofur (CEF) hydrochloride oily suspension shows potential wide applications for controlling swine

objectivesThe rational dose regimens of CEF oily suspension against

methodsThe healthy and infected pigs were intramuscularly administered CEF hydrochloride oily suspension at a single dose of 5 mg/kg, and then the plasma and pulmonary epithelial lining fluid (PELF) were collected at different times. The minimum inhibitory concentration (MIC), minimal bactericidal concentration, mutant prevention concentration (MPC), post-antibiotic effect (PAE), and time-killing curves were determined. Subsequently, the area under the curve by the MIC (AUC

resultsThe peak concentration, the area under the concentration-time curve, and the time to peak for PELF's DFC were 24.76 ± 0.92 µg/mL, 811.99 ± 54.70 μg·h/mL, and 8.00 h in healthy pigs, and 33.04 ± 0.99 µg/mL, 735.85 ± 26.20 μg·h/mL, and 8.00 h in infected pigs, respectively. The MIC of PELF's DFC against

conclusionsA rational dosage regimen was recommended, and it could assist in increasing the treatment effectiveness of CEF hydrochloride oily suspension against

Indexed as

Streptococcus suisAnimalsCephalosporinsDose-Response Relationship, DrugMicrobial Sensitivity TestsStreptococcal InfectionsSwineceftiofurCephalosporinsCeftiofur hydrochloridepharmacodynamic (PD) modelpharmacokinetic (PK)pigsStreptococcus suis

Identifiers

PMID34854264
PMCPMC8636649
OpenAlexW3164732824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.