ArticleHuman brain mapping2022
Cortical iron mediates age-related decline in fluid cognition.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Assessing Age-Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains.NMR in biomedicine · 2026Article
- White-matter connectivity shapes visual and semantic representations in the aging brain.bioRxiv : the preprint server for biology · 2026Article
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Iron dysregulation in cerebral small vessel disease: A quantitative susceptibility mapping study revealing spatial patterns and cognitive predictive value.The journal of prevention of Alzheimer's disease · 2026Observational
- Study protocol for the Champaign-Urbana population study.Frontiers in neuroimaging · 2026Article
- Using QSM to investigate the iron deposition patterns in deep gray matter nuclei during the aging process in healthy populations.Frontiers in aging neuroscience · 2026Article
- The brain-gut-muscle axis: a mechanism for exercise-mediated protection in brain aging.Frontiers in aging neuroscience · 2026Review
- Imaging Developmental Trajectories of Laminar Magnetic Susceptibility Throughout Adulthood in Human Brain Cortex.Human brain mapping · 2025Article
- Prediction of Post-Stroke Cognitive Impairment Based on Iron Metabolism Parameters: Results From A Prospective Study.Molecular neurobiology · 2025Article
- Imaging of Cerebral Iron as an Emerging Marker for Brain Aging, Neurodegeneration, and Cerebrovascular Diseases.Brain sciences · 2025Review
- Increased cortical iron deposition in glioma patients: a quantitative susceptibility mapping study.Journal of neuro-oncology · 2025Article
- Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging.Neurobiology of aging · 2025Article
- Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study.Neurobiology of aging · 2025Article
- Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping.Journal of diabetes · 2025Observational
- The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition.Brain communications · 2025Article
- Brain Iron in signature regions relating to cognitive aging in older adults: the Taizhou Imaging Study.Alzheimer's research & therapy · 2024Article
- Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Advanced BRain Imaging on ageing and Memory (ABRIM) data collection: Study design, data processing, and rationale.PloS one · 2024Article
- Review
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Brain iron dyshomeostasis disrupts various critical cellular functions, and age-related iron accumulation may contribute to deficient neurotransmission and cell death. While recent studies have linked excessive brain iron to cognitive function in the context of neurodegenerative disease, little is known regarding the role of brain iron accumulation in cognitive aging in healthy adults. Further, previous studies have focused primarily on deep gray matter regions, where the level of iron deposition is highest. However, recent evidence suggests that cortical iron may also contribute to cognitive deficit and neurodegenerative disease. Here, we used quantitative susceptibility mapping (QSM) to measure brain iron in 67 healthy participants 18-78 years of age. Speed-dependent (fluid) cognition was assessed from a battery of 12 psychometric and computer-based tests. From voxelwise QSM analyses, we found that QSM susceptibility values were negatively associated with fluid cognition in the right inferior temporal gyrus, bilateral putamen, posterior cingulate gyrus, motor, and premotor cortices. Mediation analysis indicated that susceptibility in the right inferior temporal gyrus was a significant mediator of the relation between age and fluid cognition, and similar effects were evident for the left inferior temporal gyrus at a lower statistical threshold. Additionally, age and right inferior temporal gyrus susceptibility interacted to predict fluid cognition, such that brain iron was negatively associated with a cognitive decline for adults over 45 years of age. These findings suggest that iron may have a mediating role in cognitive decline and may be an early biomarker of neurodegenerative disease.
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