Evidence map›Paper›PMID 34854011›Full record

ArticleMolecular biology reports2022

Exosomal miR-19a decreases insulin production by targeting Neurod1 in pancreatic cancer associated diabetes.

Jiaojiao Su, Wenjing Pang, Aisen Zhang, Lei Li, Weiyan Yao, Xin Dai

Abstract read
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In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jiaojiao Su *Department of Gastroenterology, Lu'an Hospital of Anhui Medical University, Lu'an, China.
Wenjing Pang *Digestive Disease Research and Clinical Translation Center, Shanghai Jiaotong University, Shanghai, China. pangwj83@126.com.ORCID http://orcid.org/0000-0001-6828-7907
Aisen ZhangJiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical, Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Lei LiDigestive Disease Research and Clinical Translation Center, Shanghai Jiaotong University, Shanghai, China.
Weiyan YaoDepartment of Gastroenterology, Shanghai Jiaotong University School of Medicine Affiliating Shanghai Ruijin Hospital, Shanghai, China.
Xin DaiDepartment of Gastroenterology, Shanghai Jiaotong University School of Medicine Affiliating Shanghai Ruijin Hospital, Shanghai, China. daixinzz730@163.com.
Ruijin Hospital · CNShanghai Jiao Tong University · CNAnhui Medical University · CNNanjing Medical University · CN

Funding

National Natural Science Foundation of China 81802304
6 · The paper itself

Abstract

backgroundNew onset diabetes mellitus demonstrates a roughly correlation with pancreatic cancer (PaC), which is unique in PaC and was named as PaC-induced DM, but the inner mechanism remains unclear. Exosomes mediate intercellular communication and bearing microRNAs might be direct constituent of effect in target cells. METHODS AND

resultsThe isolated exosomes from PaC cells were used to treat pancreatic β cells or the primary mice islets, and the glucose stimulated insulin secretions were measured. We validated the exosomal miR-19a from PaC cells to be an important mediator in the down regulation of insulin secretion by targeting Neurod1, the validated gene involved in insulin secretion, by using the quantitative real-time PCR, western blot, and promoter luciferase activity. The relative insulin, cAMP and Ca

conclusionsOur study indicated that signal changes between cancer cells and β cells via exosomes might be important in the pathogenesis of PaC-induced DM and supplemented the pathogenesis of PaC-induced DM and provide a possible access of PaC screening strategy.

Indexed as

Diabetes MellitusExosomesInsulin-Secreting CellsMicroRNAsPancreatic NeoplasmsAnimalsBasic Helix-Loop-Helix ProteinsHumansInsulinMiceBasic Helix-Loop-Helix ProteinsInsulinMicroRNAsMIRN19A microRNA, humanMIRN19a microRNA, mouseNEUROD1 protein, humanNeurod1 protein, mouseExosomemiR-19aPancreatic neoplasmβ cell dysfunction

Identifiers

PMID34854011
OpenAlexW3215491177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.