Evidence map›Paper›PMID 34853972›Full record

ArticleBulletin of experimental biology and medicine2021

Biomarkers CDX2, CK20, CK7 in Schoolchildren with Gastritis in the Realization of Familial Predisposition of Stomach Cancer.

T V Polivanova, E V Kasparov, V A Vshivkov, O V Peretyatko

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Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

T V PolivanovaFederal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences - Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
E V KasparovFederal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences - Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
V A VshivkovFederal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences - Research Institute of Medical Problems of the North, Krasnoyarsk, Russia. vitali1983@mail.ru.
O V PeretyatkoFederal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences - Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
Research Institute of Medical Problems of the North · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the association of expression of CDX2, CK20, CK7 proteins with familial predisposition to stomach cancer in schoolchildren with gastritis and its activity. Gastroscopy with biopsy of the gastric mucosa was performed in 89 schoolchildren aged 7-17 years with gastrointestinal complaints. The morphological study included the diagnosis of gastritis (Sydney classification) and the presence of Helicobacter pylori. The expression of CDX2, CK20, and CK7 was evaluated immunohistochemically. In children with familial predisposition to stomach cancer, the expression of CK20 in the stomach body was significantly increased (p=0.0225). In addition, the expression of CK20 (p=0.0979) and CDX2 (p=0.0849) tended to insrease in the antral compartment. No significant differences in the expression of CK7 in the gastric antrum and body were found. Some features of the expression of CDX2, CK20, and CK7 proteins in children with family predisposition to stomach cancer were revealed.

Indexed as

AdenocarcinomaAdolescentBiomarkers, TumorCDX2 Transcription FactorChildFemaleGastric MucosaGastritisGenetic Predisposition to DiseaseHelicobacter InfectionsHelicobacter pyloriHumansKeratin-20Keratin-7MalePrecancerous ConditionsBiomarkers, TumorCDX2 protein, humanCDX2 Transcription FactorKeratin-20Keratin-7KRT20 protein, humanbiomarkerschildrengastritisgenetic predispositionstomach cancer

Identifiers

PMID34853972
OpenAlexW3195769541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.