Evidence map›Paper›PMID 34853906›Full record

ReviewAAPS PharmSciTech2021

Transfersomes: a Revolutionary Nanosystem for Efficient Transdermal Drug Delivery.

Muhammad Waseem Akram, Humzah Jamshaid, Fiza Ur Rehman, Muhammad Zaeem, Jehan Zeb Khan, Ahmad Zeb

Abstract readReview
PubMed Publisher
In one paragraph

Review in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad Waseem AkramDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Humzah JamshaidDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan. humzahjamshaid@gmail.com.
Fiza Ur RehmanDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan. drfizaurrehman@gmail.com.
Muhammad ZaeemSchool of Pharmaceutical Sciences of Wenzhou Medical University, Wenzhou, People's Republic of China.
Jehan Zeb KhanDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Ahmad ZebDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transdermal delivery system has gained significance in drug delivery owing to its advantages over the conventional delivery systems. However, the barriers of stratum corneum along with skin irritation are its major limitations. Various physical and chemical techniques have been employed to alleviate these impediments. Among all these, transfersomes have shown potential for overcoming the associated limitations and successfully delivering therapeutic agents into systemic circulation. These amphipathic vesicles are composed of phospholipids and edge activators. Along with providing elasticity, edge activator also affects the vesicular size and entrapment efficiency of transfersomes. The mechanism behind the enhanced permeation of transfersomes through the skin involves their deformability and osmotic gradient across the application site. Permeation enhancers can further enhance their permeability. Biocompatibility; capacity for carrying hydrophilic, lipophilic as well as high molecular weight therapeutics; deformability; lesser toxicity; enhanced permeability; and scalability along with potential for surface modification, active targeting, and controlled release render them ideal designs for efficient drug delivery. The current review provides a brief account of the discovery, advantages, composition, synthesis, comparison with other cutaneous nano-drug delivery systems, applications, and recent developments in this area.

Indexed as

Drug CarriersLiposomesAdministration, CutaneousDrug Delivery SystemsSkinSkin AbsorptionDrug CarriersLiposomesCutaneous nano-drug delivery systemsNanotechnologyPermeation enhancerTransdermal drug deliveryTransfersomes

Identifiers

PMID34853906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.