Evidence map›Paper›PMID 34853703›Full record

ArticleSouthern African journal of HIV medicine2021

Five years after Treat All implementation: Botswana's HIV response and future directions in the era of COVID-19.

Keith Jefferis, Ava Avalos, Heston Phillips, Mpho Mmelesi, Dinah Ramaabya, Bornapate Nkomo, Charles Muthoga, Joseph N Jarvis, Siphiwe Ratladi, Robert Selato and 1 more

Open access · goldAbstract read
In one paragraph

Article in Southern African journal of HIV medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Global Measures of HIV Care Accessibility Across Urban, Suburban, and Rural Areas.Journal of urban health : bulletin of the New York Academy of Medicine · 2025
    Article
  2. SAHCS 2021 Conference Summary.Southern African journal of HIV medicine · 2022
    Article
  3. Southern African journal of HIV medicine · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Keith JefferisE-consult Botswana, Gaborone, Botswana.ORCID https://orcid.org/0000-0002-4583-2375
Ava AvalosCareena Centre for Health, Gaborone, Botswana.ORCID https://orcid.org/0000-0003-4111-7072
Heston PhillipsUNAIDS, Lusaka, Zambia.ORCID https://orcid.org/0000-0003-2183-5878
Mpho MmelesiUNAIDS, Gaborone, Botswana.ORCID https://orcid.org/0000-0001-6941-8120
Dinah RamaabyaBotswana Ministry of Health and Wellness, Gaborone, Botswana.ORCID https://orcid.org/0000-0002-6066-2714
Bornapate NkomoBotswana Ministry of Health and Wellness, Gaborone, Botswana.ORCID https://orcid.org/0000-0002-9940-5985
Charles MuthogaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID https://orcid.org/0000-0002-3032-4829
Joseph N JarvisBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID 0000-0003-1459-5554
Siphiwe RatladiNational AIDS and Public Health Agency, Gaborone, Botswana.ORCID https://orcid.org/0000-0002-5243-0542
Robert SelatoNational AIDS and Public Health Agency, Gaborone, Botswana.ORCID https://orcid.org/0000-0003-0448-0278
John StoverAvenir Health, Glastonbury, United States of America.ORCID https://orcid.org/0000-0001-7236-1989
Joint United Nations Programme on HIV/AIDS · CHMinistry of Health · BWPublic Health Agency · GBAvenir Health · USBotswana Harvard AIDS Institute Partnership · BWBotswana Open University · BWLondon School of Hygiene & Tropical Medicine · GB

Funding

Medical Research Council MC_PC_MR/P006922/1
6 · The paper itself

Abstract

backgroundAs the relentless coronavirus disease-2019 (COVID-19) pandemic continues to spread across Africa, Botswana could face challenges maintaining the pathway towards control of its HIV epidemic.

objectiveUtilising the Spectrum GOALS module (GOALS-2021), the 5-year outcomes from the implementation of the Treat All strategy were analysed and compared with the original 2016 Investment Case (2016-IC) projections. Future impact of adopting the new Joint United Nations Programme on HIV/AIDS (UNAIDS) Global AIDS Strategy (2021-2026) targets and macroeconomic analysis estimating how the financial constraints from the COVID-19 pandemic could impact the available resources for Botswana's National HIV Response through 2030 were also considered.

methodProgrammatic costs, population demographics, prevention and treatment outputs were determined. Previous 2016-IC data were uploaded for comparison, and inputs for the GOALS, AIM, DemProj, Resource Needs and Family Planning modules were derived from published reports, strategic plans, programmatic data and expert opinion. The economic projections were recalibrated with consideration of the impact of the COVID-19 pandemic.

resultsDecreases in HIV infections, incidence and mortality rates were achieved. Increases in laboratory costs were offset by estimated decreases in the population of people living with HIV (PLWH). Moving forward, young women and others at high risk must be targeted in HIV prevention efforts, as Botswana transitions from a generalised to a more concentrated epidemic.

conclusionThe Treat All strategy contributed positively to decreases in new HIV infections, mortality and costs. If significant improvements in differentiated service delivery, increases in human resources and HIV prevention can be realised, Botswana could become one of the first countries with a previously high-burdened generalised HIV epidemic to gain epidemic control, despite the demands of the COVID-19 pandemic.

Indexed as

BotswanaCOVID-19economic modellingGOALSSpectrumtreat all

Identifiers

PMID34853703
PMCPMC8602965
OpenAlexW3207018477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.