ReviewClinics in colon and rectal surgery2021
Defining Anastomotic Leak and the Clinical Relevance of Leaks.
Review in Clinics in colon and rectal surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Efficacy and safety of indocyanine green fluorescence imaging in colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.International journal of colorectal disease · 2025Pooled it
- Laparoscopic natural orifice specimen extraction for diverticular disease: a systematic review.Surgical endoscopy · 2025Pooled it
- Gut microbiota and postoperative complications in colorectal surgery and its potential association with intestinal permeability and NLRP6 inflammasome.Frontiers in immunology · 2025Pooled it
- Indocyanine Green Fluorescence Imaging for Colorectal Surgery: A Health Technology Assessment.Ontario health technology assessment series · 2025Pooled it
- Application of fluorescence-guided surgery in the acute care setting: a systematic literature review.Langenbeck's archives of surgery · 2023Pooled it
- Review
- Postoperative anastomotic leakage after colon cancer surgery may reduce long-term survival.International journal of colorectal disease · 2026Article
- Costs associated with anastomotic leak after left-sided colorectal surgery: retrospective real-world study in England.BJS open · 2026Article
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Exploring Collaboration Breakdowns Between Provider Teams and Patients in Post-Surgery Care.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2026Article
- Understanding Anastomotic Healing in Colo-Rectal Surgery; a Multicentric 5-Year Analysis of Predictive Factors for Integrity and Fistula Formation.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic accuracy of C-reactive protein in detecting anastomotic leakage after minimally invasive rectal cancer surgery.Surgical endoscopy · 2026Article
- Invited Commentary: Reducing the Risk of Anastomotic Leak After Rectal Cancer Resection.World journal of surgery · 2026Article
- Left internal iliac artery stenosis as a risk factor for anastomotic leakage after left-sided colorectal surgery.Frontiers in surgery · 2026Article
- Impact of Transanal Drainage Tube Placement on Anastomosis Leakage Incidence After Rectal Cancer Surgery.Life (Basel, Switzerland) · 2025Article
- Reduction in anastomotic leakage by fluorescent laparoscopic resection for ultra-low rectal cancer: a propensity-matched analysis with BMI stratification.Updates in surgery · 2025Article
- Tannin-bearing hydrogel adhesives with enhanced mechanical and adhesion strength in response to protein leakage.Biomaterials science · 2025Article
- Development of a novel rat model for pancreaticoduodenectomy.Scientific reports · 2025Article
- Assessment of colonic interposition graft using indocyanine green: expanding fluorescence imaging techniques in gastrointestinal surgery.Journal of surgical case reports · 2025Article
- Development of a Clinical Prediction Model for Anastomotic Leakage in Colorectal Surgery.JAMA network open · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgeons universally dread gastrointestinal anastomotic leaks, yet the precise definition is not widely agreed on despite international consensus guidelines. Likewise, leaks are not uniformly reported which makes comparisons across studies flawed. Leak rates range from 1 to 3% for ileocolonic, 0.5 to 18% for colorectal, and 5 to 19% for coloanal anastomoses. The sequelae of an anastomotic leak vary but generally correlate with the need for a change in clinical management, from minimal changes to the need for reoperation. Short- and long-term outcomes can be life-altering or life-threatening. Temporary or permanent stomas may be necessary and low pelvic anastomotic leaks may affect bowel function. For cancer patients, leaks can delay treatment and negatively affect oncologic outcomes. In Crohn's patients, leaks are associated with higher recurrence rates. In essence, the lack of agreement on the definition of an anastomotic leak inhibits meaningful understand of its epidemiology, prevention, and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.