Evidence map›Paper›PMID 34853474›Full record

ArticleNature2021

Activation of homologous recombination in G1 preserves centromeric integrity.

Duygu Yilmaz, Audrey Furst, Karen Meaburn, Aleksandra Lezaja, Yanlin Wen, Matthias Altmeyer, Bernardo Reina-San-Martin, Evi Soutoglou

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Targeting ubiquitination in disease and therapy.Signal transduction and targeted therapy · 2025
    Review
  9. Article
  10. Article
  11. Emerging drivers of DNA repeat expansions.Biochemical Society transactions · 2025
    Review
  12. G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Recurrent DNA nicks drive massive expansions of (GAA)Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Duygu YilmazInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.ORCID http://orcid.org/0000-0002-4009-3147
Audrey FurstInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Karen MeaburnGenome Damage and Stability Centre, Sussex University, School of Life Sciences, University of Sussex, Brighton, UK.
Aleksandra LezajaDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Yanlin WenDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Matthias AltmeyerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-3780-1170
Bernardo Reina-San-MartinInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.ORCID http://orcid.org/0000-0003-2083-6166
Evi SoutoglouInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France. E.Soutoglou@sussex.ac.uk.ORCID http://orcid.org/0000-0002-3724-5613
Inserm · FRUniversity of Zurich · CHUniversity of Sussex · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Centromeric integrity is key for proper chromosome segregation during cell division

Indexed as

Chromosomal Proteins, Non-HistoneDNA-Binding ProteinsDNA RepairCentromereCentromere Protein AChromosome SegregationDNAHistonesHomologous RecombinationCentromere Protein AChromosomal Proteins, Non-HistoneDNADNA-Binding ProteinsHistones

Identifiers

PMID34853474
OpenAlexW3215468326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.