Evidence map›Paper›PMID 34853430›Full record

Trial reportPediatric research2022

Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms.

Ayberk Akat, Seda Yilmaz Semerci, Osman Mutluhan Ugurel, Aysegul Erdemir, Olivier Danhaive, Merih Cetinkaya, Dilek Turgut-Balik

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03467828 (Investigation of Polymorphisms Defined in Specific Genes Which Are Associated With Bronchopulmonary Dysplasia In Turkish Population), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03467828 nacompletednot on this map

Investigation of Polymorphisms Defined in Specific Genes Which Are Associated With Bronchopulmonary Dysplasia In Turkish Population

TypeinterventionalSponsorSeda Yilmaz SemerciRan2017 to 2018Enrolled196ConditionsBronchopulmonary DisplasiaArmspolymorphism analyzing
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ayberk AkatBioengineering Department, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Davutpasa, Istanbul, Turkey.
Seda Yilmaz SemerciNeonatal Intensive Care Unit, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
Osman Mutluhan UgurelBioengineering Department, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Davutpasa, Istanbul, Turkey.
Aysegul ErdemirDepartment of Molecular Biology and Genetics, Faculty of Arts and Science, Yıldız Technical University, Davutpasa, Istanbul, Turkey.
Olivier DanhaiveDivision of Neonatology, St-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
Merih CetinkayaNeonatal Intensive Care Unit, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Health Sciences University, Istanbul, Turkey.
Dilek Turgut-BalikBioengineering Department, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Davutpasa, Istanbul, Turkey. dilekbalik@gmail.com.
Yıldız Technical University · TRSağlık Bilimleri Üniversitesi · TRAltınbaş University · TRUCLouvain · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimGenetic variants contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study is to evaluate the association of 45 SNPs with BPD susceptibility in a Turkish premature infant cohort.

methodsInfants with gestational age <32 weeks were included. Patients were divided into BPD or no-BPD groups according to oxygen need at 28 days of life, and stratified according to the severity of BPD. We genotyped 45 SNPs, previously identified as BPD risk factors, in 192 infants.

resultsA total of eight SNPs were associated with BPD risk at allele level, two of which (rs4883955 on KLF12 and rs9953270 on CHST9) were also associated at the genotype level. Functional relationship maps suggested an interaction between five of these genes, converging on WNT5A, a member of the WNT pathway known to be implicated in BPD pathogenesis. Dysfunctional CHST9 and KLF12 variants may contribute to BPD pathogenesis through an interaction with WNT5A.

conclusionsWe suggest investigating the role of SNPs on different genes which are in relation with the Wnt pathway in BPD pathogenesis. We identified eight SNPs as risk factors for BPD in this study. In-silico functional maps show an interaction of the genes harboring these SNPs with the WNT pathway, supporting its role in BPD pathogenesis.

trial registrationNCT03467828. IMPACT: It is known that genetic factors may contribute to the development of BPD in preterm infants. Further studies are required to identify specific genes that play a role in the BPD pathway to evaluate them as a target for therapeutic interventions. Our study shows an association of BPD predisposition with certain polymorphisms on MBL2, NFKBIA, CEP170, MAGI2, and VEGFA genes at allele level and polymorphisms on CHST9 and KLF12 genes at both allele and genotype level. In-silico functional mapping shows a functional relationship of these five genes with WNT5A, suggesting that Wnt pathway disruption may play a role in BPD pathogenesis.

Indexed as

Bronchopulmonary DysplasiaMannose-Binding LectinGenetic Predisposition to DiseaseHumansInfantInfant, NewbornInfant, PrematureKruppel-Like Transcription FactorsOxygenPolymorphism, Single NucleotideSulfotransferasesWnt Signaling PathwayCHST9 protein, humanKLF12 protein, humanKruppel-Like Transcription FactorsMannose-Binding LectinMBL2 protein, humanOxygenSulfotransferases

Identifiers

PMID34853430
OpenAlexW3215799080

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.