ArticleEuropean journal of clinical nutrition2022
The effect of different intravenous lipids on free bilirubin levels in premature infants.
Article in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Unbound free fatty acids from intralipid displace bilirubin from albumin, comparable to sulfisoxazole.Pediatric research · 2026Article
- Displacement of Bilirubin From Albumin by Omegaven and Intralipid.Journal of pediatric surgery · 2025Article
- Effects of lipid emulsions on unbound bilirubin and response to phototherapy in preterm infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
backgroundIntravenous lipid emulsions are commonly used as a part of parenteral nutrition in premature infants. The potential bilirubin-displacing effects of high free fatty acid (FFA) levels during lipid infusions are known. Levels of free bilirubin (FB) predict the risk of bilirubin neurotoxicity more accurately than indirect serum bilirubin levels. In the present study, we decided to compare the effect of two different lipid solutions on free bilirubin and free fatty acids levels in premature infants.
methodsInfants were grouped into two groups according to intravenous lipid preparations: Infants in Group 1 received lipid emulsion containing olive oil + soybean oil and Group 2 received containing olive oil + soybean oil + fish oil. The blood samples were gained when lipid intake was 3.5 g/kg/day and FFA and FB levels were analyzed.
resultsSerum FFA and FB levels were similar in groups (p = 0.26 and 0.69 respectively). There were significant correlation between serum FFA and FB levels in Group 1 (r = 0.74, p < 0.001) and in Group 2 (r = 0.92, p < 0.001).
conclusionBoth lipid preparations seem to have similar effects on free bilirubin and free fatty acid levels in premature newborns.
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