Trial reportScientific reports2021
Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9.
Open access · goldAbstract readComparative StudyRandomized Controlled Trial
In one paragraph
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Dysregulation of MMP-2 and MMP-9 in Post-COVID-19 and IPF: Correlations with Systemic Inflammation and Endothelial Dysfunction.Journal of clinical medicine · 2026Article
- Amplified inflammatory and immune responses in viral-associated pulmonary aspergillosis.Frontiers in cellular and infection microbiology · 2026Article
- Longitudinal trajectories of hematological indices and serum metalloproteinases-2 and 9 over 1 year after moderate and severe COVID-19.Frontiers in medicine · 2026Article
- Reduction in ACE2 expression in peripheral blood mononuclear cells during COVID-19 - implications for post COVID-19 conditions.BMC infectious diseases · 2024Article
- Article
- Synergistic effects of COVID-19 and Pseudomonas aeruginosa in chronic obstructive pulmonary disease: a polymicrobial perspective.Molecular and cellular biochemistry · 2024Review
- Clinical effects of traditional Chinese herbal medicine management in patients with COVID-19 sequelae: A hospital-based retrospective cohort study in Taiwan.International journal of medical sciences · 2024Article
- Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study.Frontiers in immunology · 2024Article
- Coagulopathy and adverse outcomes in hospitalized patients with COVID-19: results from the NOR-Solidarity trial.Research and practice in thrombosis and haemostasis · 2024Article
- Elevated matrix metalloproteinase‑9 expression is associated with COVID‑19 severity: A meta‑analysis.Experimental and therapeutic medicine · 2023Article
- Interactions and clinical implications of serological and respiratory variables 3 months after acute COVID-19.Clinical and experimental medicine · 2023Observational
- Advances in Biomarkers for Diagnosis and Treatment of ARDS.Diagnostics (Basel, Switzerland) · 2023Review
- Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity.Nature communications · 2023Observational
- Article
- Earliest histopathological changes in COVID-19 pneumonia with comprehensive gene expression analyses: A case series study.Histology and histopathology · 2023Article
- The potential role of SARS-CoV-2 infection in acute coronary syndrome and type 2 myocardial infarction (T2MI): Intertwining spread.Immunity, inflammation and disease · 2023Review
- A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19.ERJ open research · 2023Article
- Distinct Features of Vascular Diseases in COVID-19.Journal of inflammation research · 2023Review
- Interstitial Pulmonary Fibrosis and Extensive Dendriform Ossification with Persistent Viral Load: A Rare Presentation of Post-COVID-19 Condition in Need of Lung Transplantation.Pathobiology : journal of immunopathology, molecular and cellular biology · 2023Article
- Review of Medical Studies on COVID-19 During the Pandemic Period.The Eurasian journal of medicine · 2022Article
Corrections and comments
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Authors and funding
28 authors at 20 institutions in 1 country.
Tøri Vigeland LerumDepartment of Pulmonary Medicine, Oslo University Hospital Ullevål, Nydalen, Postboks 4950, 0424, Oslo, Norway. tori.lerum@gmail.com.ORCID 0000-0001-8326-9993
Niklas Nyboe MaltzahnOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Pål AukrustInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Marius TrøseidInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Katerina Nezvalova HenriksenDepartment of Haematology, Oslo University Hospital, Oslo, Norway.
Trine KåsineDivision of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway.
Anne-Ma Dyrhol-RiiseInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.ORCID 0000-0003-4009-4032
Birgitte StiksrudDepartment of Infectious Diseases, Oslo University Hospital, Ullevål, Oslo, Norway.
Mette HaugliInfectious Diseases Department, Sørlandet Hospital SSK, Kristiansand, Norway.
Bjørn BlombergDepartment of Medicine, Haukeland University Hospital, Bergen, Norway.
Bård Reiakvam KittangDepartment of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.
Asgeir JohannessenInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Raisa HannulaDepartment of Infectious Diseases, Trondheim University Hospital, Trondheim, Norway.
Saad AballiDepartment of Infectious Diseases, Østfold Hospital Trust Kalnes, Grålum, Norway.
Anders Benjamin KildalDepartment of Anaesthesiology and Intensive Care, University Hospital of North Norway, Tromsø, Norway.
Ragnhild EikenDepartment of Infectious Diseases, Innlandet Hospital Trust, Lillehammer, Norway.
Tuva Børresdatter DahlDivision of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway.
Fridtjof Lund-JohansenDivision of Laboratory Medicine, Department of Immunology, Oslo University Hospital, Oslo, Norway.
Fredrik MüllerInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Jezabel Rivero RodriguezDepartment of Radiology and Nuclear Medicine, Oslo University Hospital Ullevål, Oslo, Norway.
Carin MeltzerDepartment of Radiology and Nuclear Medicine, Oslo University Hospital Ullevål, Oslo, Norway.
Gunnar EinvikInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Thor UelandInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Inge Christoffer OlsenDepartment of Research Support for Clinical Trials, Oslo University Hospital, Oslo, Norway.
NOR-SOLIDARITY Consortium
Andreas Barratt-DueDivision of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway.
Trond Mogens AaløkkenInstitute of Clinical Medicine, University of Oslo, Blindern, Postboks 1171, 0318, Oslo, Norway.
Ole Henning SkjønsbergDepartment of Pulmonary Medicine, Oslo University Hospital Ullevål, Nydalen, Postboks 4950, 0424, Oslo, Norway.
Oslo University Hospital · NODiakonhjemmet Hospital · NOVestre Viken Hospital Trust · NOHaukeland University Hospital · NOØstfold Hospital Trust · NOUniversity of Oslo · NOInnlandet Hospital Trust · NOLevanger Hospital · NOLovisenberg Diakonale Høgskole · NOUniversity Hospital of North Norway · NOAkershus University Hospital · NOÅlesund Hospital · NOHaraldsplass Diakonale Sykehus · NOHelse Førde · NOPrivatsykehuset Haugesund · NOSørlandet Hospital Arendal · NOSørlandet Sykehus · NOStavanger University Hospital · NOSt Olav's University Hospital · NOSykehuset i Vestfold · NO
Funding
The National Program for Clinical Therapy Research in the Specialist Health Service. Grant no. 2020201
Abstract
The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DL
Indexed as
COVID-19 Drug TreatmentViral LoadAdenosine MonophosphateAgedAlanineAntibody FormationAntimalarialsAntiviral AgentsCOVID-19FemaleHospitalizationHumansHydroxychloroquineLung DiseasesMaleMatrix Metalloproteinase 9Adenosine MonophosphateAlanineAntimalarialsAntiviral AgentsHydroxychloroquineMatrix Metalloproteinase 9MMP9 protein, humanremdesivir
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.