Evidence map›Paper›PMID 34853360›Full record

Trial reportScientific reports2021

Effect of 970 nm low-level laser therapy on orthodontic tooth movement during Class II intermaxillary elastics treatment: a RCT.

Bénédicte Pérignon, Octave Nadile Bandiaky, Caroline Fromont-Colson, Stéphane Renaudin, Morgane Peré, Zahi Badran, Madline Cuny-Houchmand, Assem Soueidan

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02181439 (Single-center, Controlled, Randomized and Double-blind Study Evaluating the Laser Diode Effect on the Kinetics of Orthodontic Tooth Movement.), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02181439 nacompletednot on this map

Single-center, Controlled, Randomized and Double-blind Study Evaluating the Laser Diode Effect on the Kinetics of Orthodontic Tooth Movement.

TypeinterventionalSponsorNantes University HospitalRan2014 to 2018Enrolled41ConditionsClass II Canine, Intermaxillary Strength, Elastics II, Multi Fasteners Orthodontic TreatmentArms(LLLT Low Level Laser Therapy) SiroLaser advance
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Comparative assessment of the rate of maxillary canine retraction using micro-osteoperforation and low-level laser therapy : A split mouth study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. [Early orthodontic/orthopedic treatment in patients with class II sagittal anomalies. A review].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Bénédicte PérignonDepartment of Orthodontics, UIC 11, CHU de Nantes, Nantes, France.
Octave Nadile BandiakyDivision of Fixed Prosthodontics, University of Nantes, 44042, Nantes, France.
Caroline Fromont-ColsonDepartment of Orthodontics, UIC 11, CHU de Nantes, Nantes, France.
Stéphane RenaudinDepartment of Orthodontics, UIC 11, CHU de Nantes, Nantes, France.
Morgane PeréBiostatistics and Methodology Unit, Department of Clinical Research and Innovation, CHU Nantes, Nantes, France.
Zahi BadranCollege of Dental Medicine, University of Sharjah, Sharjah, UAE.
Madline Cuny-HouchmandDepartment of Orthodontics, UIC 11, CHU de Nantes, Nantes, France.
Assem SoueidanHead and Chair of Periodontology Department, Faculty of Dental Surgery, UIC 11, Rmes U1229, University of Nantes, 1 Place Alexis Ricordeau, 44042, Nantes, France. assem.soueidan@univ-nantes.fr.
Laboratoire de Thermique et Energie de Nantes · FRNantes Université · FRCentre d'Investigation Clinique de Nantes · FRCentre Hospitalier Universitaire de Nantes · FRRMeS - Regenerative Medicine and SkeletonUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective randomized clinical trial aimed to evaluate the effect of low-level laser therapy on tooth movement during Class II intermaxillary elastics treatment. Forty-two patients with Class II malocclusion were included, and their maxillary quadrants were allocated into two groups: treatment with an active diode laser and a placebo group. In each group, the time taken to obtain Class I occlusion after 6 months, rate of movement, total displacement of the maxillary canine to Class I occlusion and pain were recorded. The time to reach Class I occlusion in the active laser group (2.46 ± 2.1 months) was not significantly different from that in the placebo group (2.48 ± 2.0 months) (p = 0.938). Interestingly, the total distance of movement on the active laser side (2.27 ± 1.5 mm) was significantly greater than that on the placebo side (1.64 ± 1.3 mm) (p = 0.009). The pain levels on days 1, 2 and 3 were not significantly different between the laser and placebo sections. The rate of distance change toward Class I occlusion in the laser group (1.1 ± 0.7 mm/month) was significantly higher than that in the placebo group (0.74 ± 0.6 mm/month) (p = 0.037). Low-level laser therapy (970 nm) did not reduce the time needed to obtain Class I occlusion, but a significant acceleration in tooth movement was observed in the irradiated group.Trial registration: NCT02181439. Registered 04 July 2014- https://www.clinicaltrials.gov/ct2/results?term=cinelaser .

Indexed as

Laser TherapyLow-Level Light TherapyMalocclusion, Angle Class IITooth Movement TechniquesAdolescentChildFemaleHumansMalePainTreatment Outcome

Identifiers

PMID34853360
PMCPMC8636571
OpenAlexW3214951846

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.