Evidence map›Paper›PMID 34853325›Full record

ArticleScientific reports2021

The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion.

Kadir A Ozcan, Layla T Ghaffari, Aaron R Haeusler

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. G-Quadruplexes Formation by theMolecules (Basel, Switzerland) · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kadir A OzcanDepartment of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Layla T GhaffariDepartment of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Aaron R HaeuslerDepartment of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA. Aaron.Haeusler@jefferson.edu.
Thomas Jefferson University · USJefferson Hospital for Neuroscience · US

Funding

Nucleocentric molecular characterization of C9orf72 NRE-linked neurodegenerationR00NS091486 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2017 to 2019
$737k
A NEW HYBRID DIFFRACTOMETER FOR MACROMOLECULAR CRYSTALLOGRAPHY AND SAXS AT TJUS10OD017987 · OD · THOMAS JEFFERSON UNIVERSITY · PI CINGOLANI, GINO · 2014 to 2014
$600k
Modeling C9orf72 neuronal pathogenesis as a function of nucleotide repeat lengthR21NS116761 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2020 to 2020
$429k
A High-Throughput Crystallization Platform at JeffersonS10OD023479 · OD · THOMAS JEFFERSON UNIVERSITY · PI CINGOLANI, GINO · 2019 to 2019
$94k
NIH HHS S10 OD017987NIH HHS S10 OD023479NINDS NIH HHS R00 NS091486NINDS NIH HHS R21 NS116761
6 · The paper itself

Abstract

A nucleotide repeat expansion (NRE), (G

Indexed as

DNA MethylationDNA Repeat ExpansionG-QuadruplexesAmyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaHumansMolecular Dynamics SimulationC9orf72 ProteinC9orf72 protein, human

Identifiers

PMID34853325
PMCPMC8636472
OpenAlexW3216340579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.