Evidence map›Paper›PMID 34853307›Full record

ArticleCell death & disease2021

Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7.

Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Noncoding RNAs, Vital Players in Breast Cancer Metastasis.Breast cancer (Dove Medical Press) · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. [Tumor-associated fibroblasts promotes proliferation and migration of prostate cancer cells by suppressing FBXL3Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ziqian Yan *Department of Pathology, Weifang Medical University, Weifang, Shandong, China.
Zhimei Sheng *Department of Pathology, Weifang Medical University, Weifang, Shandong, China.
Yuanhang Zheng *Department of Pathology, Weifang Medical University, Weifang, Shandong, China.
Ruijun Feng *Department of Pathology, Weifang Medical University, Weifang, Shandong, China.
Qinpei XiaoDepartment of Pathology, Weifang Medical University, Weifang, Shandong, China.
Lihong ShiDepartment of Pharmacology, Weifang Medical University, Weifang, Shandong, China.
Hongli LiDepartment of Medicine Research Center, Weifang Medical University, Weifang, Shandong, China.
Chonggao YinDepartment of Medicine Research Center, Weifang Medical University, Weifang, Shandong, China.
Hao LuoDepartment of Pathology, Weifang Medical University, Weifang, Shandong, China.
Chong HaoDepartment of Oncology, Maternal and Child Health Care Hospital of Zibo, Zibo, Shandong, China.
Wenhao WangDepartment of Medical Oncology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.
Baogang ZhangDepartment of Pathology, Weifang Medical University, Weifang, Shandong, China. Zhangbg@wfmc.edu.cn.ORCID http://orcid.org/0000-0002-2355-6461
Weifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have shown that cancer-associated fibroblasts (CAFs) play an irreplaceable role in the occurrence and development of tumors. Therefore, exploring the action and mechanism of CAFs on tumor cells is particularly important. In this study, we compared the effects of CAFs-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion. The results showed that exosomes from both CAFs and NFs could enter into breast cancer cells and CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes. Furthermore, microRNA (miR)-18b was upregulated in CAFs-derived exosomes, and CAFs-derived exosomes miR-18b can promote breast cancer cell migration and metastasis by specifically binding to the 3'UTR of Transcription Elongation Factor A Like 7 (TCEAL7). The miR-18b-TCEAL7 pathway promotes nuclear Snail ectopic activation by activating nuclear factor-kappa B (NF-κB), thereby inducing epithelial-mesenchymal transition (EMT) and promoting cell invasion and metastasis. Moreover, CAFs-derived exosomes miR-18b could promote mouse xenograft model tumor metastasis. Overall, our findings suggest that CAFs-derived exosomes miR-18b promote nuclear Snail ectopic by targeting TCEAL7 to activate the NF-κB pathway, thereby inducing EMT, invasion, and metastasis of breast cancer. Targeting CAFs-derived exosome miR-18b may be a potential treatment option to overcome breast cancer progression.

Indexed as

AnimalsBreast NeoplasmsCancer-Associated FibroblastsFemaleHumansMiceMicroRNAsNeoplasm InvasivenessNeoplasm MetastasisNuclear ProteinsMicroRNAsMIRN18 microRNA, mouseNuclear ProteinsTCEAL7 protein, human

Identifiers

PMID34853307
PMCPMC8636636
OpenAlexW3215627959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.