Evidence map›Paper›PMID 34853178›Full record

ArticleNeurology2022

Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population.

Milou J Angevaare, Jet M J Vonk, Laiss Bertola, Laura Zahodne, Caitlin Wei-Ming Watson, Amelia Boehme, Nicole Schupf, Richard Mayeux, Mirjam I Geerlings, Jennifer J Manly

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Association of Depression Dimensions With Cognitive Functioning in Community-Dwelling Oldest-Old Adults: The LifeAfter90 Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Personality and Transition From Mild Cognitive Impairment to Normal Cognition vs Dementia.Journal of the American Medical Directors Association · 2024
    Observational
  12. Article
  13. Article
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  19. Association ofFrontiers in aging neuroscience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 4 countries.

Milou J AngevaareFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jet M J VonkFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0002-1808-8843
Laiss BertolaFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0001-5771-2576
Laura ZahodneFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0002-5763-4501
Caitlin Wei-Ming WatsonFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0001-7734-1469
Amelia BoehmeFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0002-7109-6025
Nicole SchupfFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Richard MayeuxFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mirjam I GeerlingsFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jennifer J ManlyFrom the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.J.A., J.M.J.V., L.B., L.Z., C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil. jjm71@cumc.columbia.edu.ORCID 0000-0002-9481-7497
Universidade Federal de Minas Gerais · BR

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SCHUPF, NICOLE · 1989 to 2008
$21.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging ProjectRF1AG066107 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2022
$11.4M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
NCATS NIH HHS UL1 TR001873NIA NIH HHS P01 AG007232NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG072474NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG066107NIDA NIH HHS T32 DA031098
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia.

methodsWithin a community-based cohort, diagnoses of MCI were made with a published algorithm. Diagnosis of dementia was based on clinical consensus. Cox regressions estimated hazard ratios of incident MCI associated with several predictors. Modified Poisson regressions estimated relative risks associated with predictors of diagnostic status at follow-up after incidence.

resultsAmong 2,903 cognitively normal participants at baseline, 752 developed MCI over an average of 6.3 (SD 4.5) years (incidence rate 56 per 1,000 person-years). Presence of DISCUSSION: This community-based study showed that almost half of the individuals with incident MCI diagnoses were classified as cognitively normal at follow-up. Predictors of incident MCI demonstrably differed from those of subsequent MCI course; these findings can refine expectations for cognitive and functional course of those presenting with MCI.

Indexed as

Cognitive DysfunctionCohort StudiesDisease ProgressionHumansIncidenceProportional Hazards ModelsRisk Factors

Identifiers

PMID34853178
PMCPMC8726570
OpenAlexW3215960212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.