ArticleProceedings of the National Academy of Sciences of the United States of America2021
Sensory computations in the cuneate nucleus of macaques.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex.The Journal of physiology · 2026Article
- Spatiotemporal encoding of touch signals in the human somatosensory and motor cortices.bioRxiv : the preprint server for biology · 2026Article
- A framework for quantifying the mechanics of dexterous grasp.bioRxiv : the preprint server for biology · 2026Article
- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Amorphous silicon carbide probe mechanics for insertion in the cerebral cortex of rats, pigs, and macaques.Journal of neural engineering · 2025Article
- The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states.Cell reports · 2025Article
- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Disentangling Temporal and Rate Codes in the Primate Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Implications for brainstem recovery from studies in primates after sensory loss from arm.Neural regeneration research · 2024Article
- Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.Nature communications · 2024Article
- Reduced Cerebellar Brain Inhibition and Vibrotactile Perception in Response to Mechanical Hand Stimulation at Flutter Frequency.Cerebellum (London, England) · 2024Article
- Utilization of peripheral nerve feedback at a preconscious level.Frontiers in neuroscience · 2024Article
- Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.Nature communications · 2023Article
- Regressive changes in sizes of somatosensory cuneate nucleus after sensory loss in primates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Differential Recovery of Submodality Touch Neurons and Interareal Communication in Sensory Input-Deprived Area 3b and S2 Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Predictive attenuation of touch and tactile gating are distinct perceptual phenomena.iScience · 2022Article
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Tactile nerve fibers fall into a few classes that can be readily distinguished based on their spatiotemporal response properties. Because nerve fibers reflect local skin deformations, they individually carry ambiguous signals about object features. In contrast, cortical neurons exhibit heterogeneous response properties that reflect computations applied to convergent input from multiple classes of afferents, which confer to them a selectivity for behaviorally relevant features of objects. The conventional view is that these complex response properties arise within the cortex itself, implying that sensory signals are not processed to any significant extent in the two intervening structures-the cuneate nucleus (CN) and the thalamus. To test this hypothesis, we recorded the responses evoked in the CN to a battery of stimuli that have been extensively used to characterize tactile coding in both the periphery and cortex, including skin indentations, vibrations, random dot patterns, and scanned edges. We found that CN responses are more similar to their cortical counterparts than they are to their inputs: CN neurons receive input from multiple classes of nerve fibers, they have spatially complex receptive fields, and they exhibit selectivity for object features. Contrary to consensus, then, the CN plays a key role in processing tactile information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.