Evidence map›Paper›PMID 34853153›Full record

ArticleMolecular pharmacology2022

The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the

Spencer R Pierce, Allison L Germann, Joe Henry Steinbach, Gustav Akk

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution.

Spencer R PierceDepartment of Anesthesiology (S.R.P., A.L.G., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Allison L GermannDepartment of Anesthesiology (S.R.P., A.L.G., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Joe Henry SteinbachDepartment of Anesthesiology (S.R.P., A.L.G., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Gustav AkkDepartment of Anesthesiology (S.R.P., A.L.G., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu.
Taylor Family Institute for Innovative Psychiatric Research

Funding

SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8M
NIGMS NIH HHS R01 GM108580NIGMS NIH HHS R35 GM140947
6 · The paper itself

Abstract

The GABA

Indexed as

AnimalsDehydroepiandrosterone SulfateDose-Response Relationship, DrugFemaleGABA AntagonistsHumansNeurosteroidsPregnenoloneProtein StabilityReceptors, GABA-AXenopus laevisDehydroepiandrosterone SulfateGABA AntagonistsGABRA1 protein, humanGABRB3 protein, humanGABRG2 protein, humanNeurosteroidsPregnenolonepregnenolone sulfateReceptors, GABA-A

Identifiers

PMID34853153
PMCPMC8969134
OpenAlexW3216893825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.