Evidence map›Paper›PMID 34853022›Full record

Observational studyCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2022

Survival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study.

Julian Hamfjord, Tor Åge Myklebust, Inger Kristin Larsen, Elin H Kure, Bengt Glimelius, Tormod K Guren, Kjell M Tveit, Marianne G Guren

Abstract readObservational Study
In one paragraph

Observational study in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  7. Article
  8. Best Evidence for Each Surgical Step in Minimally Invasive Right Hemicolectomy: A Systematic Review.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julian HamfjordDepartment of Oncology, Oslo University Hospital, Oslo, Norway.
Tor Åge MyklebustDepartment of Registration, Cancer Registry of Norway, Oslo, Norway.
Inger Kristin LarsenDepartment of Registration, Cancer Registry of Norway, Oslo, Norway.ORCID 0000-0002-9601-5324
Elin H KureDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-5135-9916
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-5440-791X
Tormod K GurenDepartment of Oncology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-6471-2072
Kjell M TveitInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Marianne G GurenDepartment of Oncology, Oslo University Hospital, Oslo, Norway. marianne.gronlie.guren@ous-hf.no.ORCID 0000-0003-0593-0218

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ clinically and molecularly. The main objective was to investigate stage-stratified survival and recurrence of RCC and LCC across four 10-year periods.

methodsPatients diagnosed from 1977 to 2016 with colon adenocarcinoma were included from the Cancer Registry of Norway. Primary tumor location (PTL) was defined as RCC if proximal and LCC if distal to the splenic flexure. Multivariable regressions were used to estimate HRs for overall survival (OS), recurrence-free survival (RFS), survival after recurrence (SAR), and excess HRs (eHR) for relative survival (RS).

results72,224 patients were eligible for analyses [55.1% (

conclusionsA gradually diverging and increasingly favorable prognosis was observed for patients with LCC with advanced disease over the past four decades. IMPACT: Current PTL survival disparities stress the need for further exploring targetable molecular subgroups across and within different PTLs to further improve patient outcomes.

Indexed as

AdenocarcinomaAgedColonic NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm StagingNorwayRegistriesRetrospective Studies

Identifiers

PMID34853022
PMCPMC9398128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.