ReviewFluids and barriers of the CNS2021
Microdialysis and microperfusion electrodes in neurologic disease monitoring.
Review in Fluids and barriers of the CNS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- An opto-microperfusion neural probe for multiplexed detection of optogenetically evoked neurochemical release dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of borneol on pharmacokinetics and tissue distribution of tetramethylpyrazine in transdermal patch.Drug delivery and translational research · 2026Article
- Region-specific proteomic profiling of brain interstitial fluidLab on a chip · 2026Article
- Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery.Nature metabolism · 2026Article
- Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates.Clinical and translational science · 2025Review
- Defining the Spatial Resolution of Analyte Recovery during Microperfusion-Based Sampling of Brain Parenchyma.ACS chemical neuroscience · 2024Article
- Artificial Intelligence-Enhanced Neurocritical Care for Traumatic Brain Injury : Past, Present and Future.Journal of Korean Neurosurgical Society · 2024Article
- Novel application of in vivo microdialysis in a rat Achilles tendon acute injury model.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Methodological and analytical considerations for intra-operative microdialysis.Fluids and barriers of the CNS · 2023Article
- Blood-brain barrier dysfunction in intensive care unit.Journal of intensive medicine · 2023Review
- How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches.Journal of neurochemistry · 2023Review
- Accelerating the development of implantable neurochemical biosensors by using existing clinically applied depth electrodes.Analytical and bioanalytical chemistry · 2023Article
- Development of an integrated microperfusion-EEG electrode for unbiased multimodal sampling of brain interstitial fluid and concurrent neural activity.Journal of neural engineering · 2023Article
- Toward the use of novel alternative methods in epilepsy modeling and drug discovery.Frontiers in neurology · 2023Review
- Conduction treatment of temporal lobe epilepsy in rats: the dose-effect relationship between current resistance and therapeutic effect.Frontiers in neurology · 2023Article
- Fluidic enabled bioelectronic implants: opportunities and challenges.Journal of materials chemistry. B · 2022Review
- Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid.Pharmaceutics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography (EEG) data has long been the standard of care in these patients, enabling individualized insights for therapy and revealing fundamental principles of human neurophysiology. Increasing interest exists in simultaneously measuring neurochemical biomarkers and electrophysiological data to enhance our understanding of human disease mechanisms. This review compares microdialysis, microperfusion, and implanted EEG probe architectures and performance parameters. Invasive consequences of probe implantation are also investigated along with the functional impact of biofouling. Finally, previously developed microdialysis electrodes and microperfusion electrodes are reviewed in preclinical and clinical settings. Critically, current and precedent microdialysis and microperfusion probes lack the ability to collect neurochemical data that is spatially and temporally coincident with EEG data derived from depth electrodes. This ultimately limits diagnostic and therapeutic progress in epilepsy and glioma research. However, this gap also provides a unique opportunity to create a dual-sensing technology that will provide unprecedented insights into the pathogenic mechanisms of human neurologic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.