Trial reportBMC anesthesiology2021
Comparative evaluation of pain perception with a new needle-free system and dental needle method in children: a randomized clinical trial.
Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Evaluation of Pain Perception With a New Needle-Free System and Dental Injection in Children: A Randomized Clinical Trial
Evaluation of the Effectiveness of the Comfort-In Needle-Free Injector System During Palatal Infiltrative Anesthesia in Children
Clinical Evaluation and Comparison of Pain Acceptance of Different Types of Injection Systems in Palatal Anesthesia Applied to Children
Comparison of Needle-Free Injection and Conventional Syringe in Tooth Extractions in Children: Effects on Pain, Anxiety, and Vital Signs
Assessing the Efficacy of the Comfort-in Needle-Free Injection System for Managing Pain and Anxiety During Pediatric Dental Injections: A Randomized Split-Mouth Clinical Trial
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Comparative evaluation of anesthetic delivery systems on pain, anxiety, and physiological responses in pediatric dental patients: A randomized clinical trial.Scientific reports · 2026Trial
- Comparison of five anesthetic delivery systems for palatal infiltration: A randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2026Trial
- Comparison of behavioural, physiological, and self-reported pain responses in Pakistani children with dental pain: a descriptive cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Trial
- Anesthetic Efficacy, Injection Pain and Pulse-rate Effect of Needle-free Injection in Pulpal Anesthesia of Maxillary Premolars with Irreversible Pulpitis: Randomised Clinical Study.European endodontic journal · 2025Trial
- Pain and Anxiety Levels During Dental Restorations in Primary Molars: INJEX Needleless System vs Traditional Syringe.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Comparative evaluation of the effectiveness of transcutaneous electric nerve stimulation and photobiostimulation using diode laser prior to local anesthesia administration in children undergoing bilateral orthodontic extraction- a randomized controlled clinical trial.Lasers in medical science · 2025Trial
- Efficacy of articaine anesthesia with needle-free/Comfort-in method and conventional needle injection in dental patients with irreversible pulpitis: a randomized clinical trial.Clinical oral investigations · 2024Trial
- Efficacy and Pain Perception of a Comfort-in™ for Palatal Anesthesia in Pediatric Dental Patients: A Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2026Article
- Review
- Clinical evaluation of different types of injection systems and comparison of pain acceptance in palatal anesthesia in pediatric patients: a randomized controlled split-mouth study.Journal of dental anesthesia and pain medicine · 2025Article
- Comparative Efficacy of MadaJetFrontiers in dentistry · 2025Article
- Comparative Evaluation of New Needleless Local Anesthetic System (INJEX) and Conventional Syringe Needle Technique during Pulpotomy Treatment: A Randomized Clinical Trial.Children (Basel, Switzerland) · 2024Article
- Advances in pediatric dentistry: new approaches to pain control and anxiety reduction in children - a narrative review.Journal of dental anesthesia and pain medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain control during dental procedures is one of the most important topics related to behavior management in children. This study aims to compare the pain perception associated with a needle-free system (Comfort-In™) and the dental needle method during filling and pulpotomy treatments in children.
methodsThe study included teeth that required treatment (pulpotomy or filling treatment) in 56 patients aged 4 to 11 years with no systemic problems or history of allergy. Patients were randomly divided into the needle-free system group (filling treatment, n = 13; pulpotomy, n = 15) and dental needle method group (filling treatment, n = 14; pulpotomy, n = 14). For pulpotomy and filling treatment performed with 0.3 mL anesthesia, the active ingredient of which is 2% lidocaine and 1/80000 epinephrine. The patients' behavior before the procedure was evaluated by a pediatric dentist using the Frankl Behavior Scale. The pain intensity was assessed Immediately after injection (induction), during treatment (treatment), and at the end of the treatment (post treatment) by the Wong-Baker Faces Pain Scale.
resultsThe median (IQR-InterQuartile Range) induction pain value was 6[3-8] and 2[0-4] in dental needle method and needle-free system respectively, p < 0.001). In filling and pulpotomy treatment group, no difference between the needle and needle-free group for treatment and post-treatment pain values.
conclusionsFor pulpotomy and filling treatment, needle-free system performed with 0.3 mL anesthesia was found as effective as infiltrative anesthesia with a dental needle method.
trial registrationClinicalTrials.gov , NCT04653974 . Registered 4 December 2020 - Retrospectively registered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.