ArticleCell reports2021
Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Pooled it
- Dopamine transporter gene (Pain reports · 2026Article
- Neuroplasticity-Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain.Brain and behavior · 2026Review
- Altered static-dynamic interhemispheric connectivity and transcriptional features underlying lateralization in patients with migraine.The journal of headache and pain · 2026Article
- Chronic random sleep deprivation causes prolonged pain hypersensitivity via the anterior cingulate cortex.iScience · 2026Article
- Distinct CaMKII neurons in anterior cingulate cortex regulate anxiety-like behavior and appetite suppression in a model of inflammatory pain.Frontiers in pharmacology · 2026Article
- Recruitment of specific dopamine neuron sub-circuits by opioids.Addiction neuroscience · 2025Article
- Neural correlates of postoperative pain in patients with rotator cuff tear following arthroscopic surgery: a resting-state fMRI study.Scientific reports · 2025Article
- A switch in kappa opioid receptor signaling from inhibitory to excitatory induced by stress in a subset of cortically-projecting dopamine neurons.bioRxiv : the preprint server for biology · 2025Article
- Disruptions of morphological brain networks and their associations with multi-symptoms in children with spastic cerebral palsy.Quantitative imaging in medicine and surgery · 2025Article
- Brain compensation and volume alterations in patients with severe knee osteoarthritis: a cross-sectional neuroimaging study.Rheumatology international · 2025Article
- Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The relationship between abnormal glucose metabolism and chronic pain.Cell & bioscience · 2025Review
- Inhibitory effects of dopamine agonists on pain-responsive neurons in the central nucleus of the amygdala.Journal of neurophysiology · 2025Article
- The analgesic mechanism of electroacupuncture at the central level for neuropathic pain: a review of studies based on animal experiments.Frontiers in neurology · 2025Review
- Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation.Frontiers in neuroanatomy · 2025Article
- Mechanism of the anterior cingulate cortex in sleep regulation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Article
- Subcutaneous administration of a novel TRPM8 antagonist reverses cold hypersensitivity while attenuating the drop in core body temperature.British journal of pharmacology · 2024Article
- Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Pyramidal neurons in the anterior cingulate cortex (ACC), a prefrontal region involved in processing the affective components of pain, display hyperexcitability in chronic neuropathic pain conditions, and their silencing abolishes hyperalgesia. We show that dopamine, through D1 receptor (D1R) signaling, inhibits pyramidal neurons of mouse ACC by modulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Activation of G
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.