ArticleCell reports2021
The hippocampus and orbitofrontal cortex jointly represent task structure during memory-guided decision making.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation.Psychopharmacology · 2026Article
- The Orbitofrontal Cortex Represents the Allocentric Spatial States of Dynamic Agents Within a Static Environmental Framework.Neuroscience bulletin · 2026Article
- Spontaneous emergence of context-dependent statistical learning in humans and neural networks.iScience · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Precise temporal dynamics of ripple events support order memory in human hippocampal-cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Liver fat mediates hippocampal-orbitofrontal reward circuit disruption and cognitive-emotional impairments in MASLD.Lipids in health and disease · 2025Article
- Regional hyperconnectivity in the medial temporal lobes as a maladaptive mechanism for colorectal cancer-related cognitive decline.Scientific reports · 2025Article
- Hippocampal output suppresses orbitofrontal cortex schema cell formation.Nature neuroscience · 2025Article
- Article
- Flexible hippocampal representation of abstract boundaries supports memory-guided choice.Nature communications · 2025Article
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
- Neural correlates of decision making and executive function in suicidal thoughts and behaviors.Frontiers in psychiatry · 2025Review
- Left OFC Activation in Functional Near-Infrared Spectroscopy during an Inhibitory Control Task in an Early Years Sample: Integrating Stress Responses with Cognitive Function and Brain Activation.Developmental neuroscience · 2025Article
- Expectancy-related changes in firing of dopamine neurons depend on hippocampus.Nature communications · 2024Article
- Dentate gyrus ensembles gate context-dependent neural states and memory retrieval.Science advances · 2024Article
- Article
- The role of the human hippocampus in decision-making under uncertainty.Nature human behaviour · 2024Article
- Cognitive, Emotional, and Daily Functioning Domains Involved in Decision-Making among Patients with Mild Cognitive Impairment: A Systematic Review.Brain sciences · 2024Review
- Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring.Translational psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The hippocampus, well known for its role in episodic memory, might also be an important brain region for extracting structure from our experiences in order to guide future decisions. Recent evidence in rodents suggests that the hippocampus supports decision making by representing task structure in cooperation with the orbitofrontal cortex (OFC). Here, we examine how the human hippocampus and OFC represent task structure during an associative learning task that required learning of both context-determined and context-invariant probabilistic associations. We find that after learning, hippocampal and lateral OFC representations differentiated between context-determined and context-invariant task structures. The degree of this differentiation within the hippocampus and lateral OFC is highly correlated. These results advance our understanding of the hippocampus and suggest that the hippocampus and OFC support goal-directed behavior by representing information that guides the selection of appropriate decision strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.