ArticleCell reports2021
Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
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Who cites it
47 citing papers in PubMed, 58 citations in OpenAlex.
- T cell immunomonitoring: a comparative analysis of traditional and novel methods to quantify and characterize human antigen-specific T cells.Nature protocols · 2026Review
- Intratumoral T cell activation kills tumors regardless of T cell specificity.Nature immunology · 2026Article
- Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens.Nature immunology · 2026Article
- Sequential infection reprograms the immune landscape to shape future responses.bioRxiv : the preprint server for biology · 2026Article
- Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Sex Differences in Lung Immunity.Immunological reviews · 2026Review
- Lung tissue-resident memory T cells optimize protection by IL-10 regulation of innate immunity.The Journal of experimental medicine · 2026Article
- Human leukocyte antigen genotype modulates cytomegalovirus- and Epstein-Barr virus-specific T-cell response in healthy donors for optimized virus-specific T-cell donor selection.Frontiers in immunology · 2026Article
- Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils.Immunity · 2025Article
- Sex differences in antibody responses to influenza A/H3N2 across the life course.Research square · 2025Article
- Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8European journal of immunology · 2025Article
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- Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.Immunity · 2025Article
- High TCR Degeneracy Enhances Antiviral Efficacy of HTLV-1-Specific CTLs by Targeting Variant Viruses in HAM Patients.International journal of molecular sciences · 2025Article
- Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy.NPJ vaccines · 2025Article
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
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- Maintenance and functional regulation of immune memory to COVID-19 vaccines in tissues.Immunity · 2024Article
- A guide to adaptive immune memory.Nature reviews. Immunology · 2024Review
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Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Maya M L PoonDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA.
Eve ByingtonDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wenzhao MengDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Masaru KubotaDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Rei MatsumotoDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Alba GrifoniCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Daniela WeiskopfCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Pranay DograDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Nora LamDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Peter A SzaboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Basak Burcu UralDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Steven B WellsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Aaron M RosenfeldDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maigan A BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Todd M BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Thomas J ConnorsDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Alessandro SetteCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Peter A SimsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Eline T Luning PrakDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yufeng ShenDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu.
Columbia University Irving Medical Center · USLa Jolla Institute for Immunology · USUniversity of Pennsylvania · USUniversity of Florida · US
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MTumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MVACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7MTranscriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MViral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Peter Alan Sims · 2017 to 2026
$26.4MDevelopment of lung T cell responses in infant respiratory immunityU01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2017 to 2021
$3.9MDevelopment of lung T cell responses in infant respiratory immunityR01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2012 to 2016
$2.6MImmunobiology and alveolar physiology of the aging lungU01HL145547 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BHATTACHARYA, JAHAR, FARBER, DONNA L. · 2019 to 2022
$2.6MDevelopment of Localized T Cell Immunity in Pediatric Respiratory Tract InfectionK23AI141686 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CONNORS, THOMAS · 2019 to 2023
$973kBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kBecton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413kNCI NIH HHS P30 CA013696NCI NIH HHS P30 CA016520NCRR NIH HHS S10 RR027050NHLBI NIH HHS U01 HL145547NIAID NIH HHS K23 AI141686NIAID NIH HHS P01 AI106697NIAID NIH HHS R01 AI100119NIAID NIH HHS U01 AI100119NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI128949NIH HHS S10 OD020056
Abstract
The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that shape maintenance and function of anti-viral T cell immunity in the body by comprehensive profiling of virus-specific T cells across blood, lymphoid organs, and mucosal tissues of organ donors. We use flow cytometry, T cell receptor sequencing, single-cell transcriptomics, and cytokine analysis to profile virus-specific CD8
Indexed as
AdultAge FactorsAntiviral AgentsCD8-Positive T-LymphocytesChildChild, PreschoolCytokinesCytomegalovirusCytomegalovirus InfectionsFemaleHumansImmunologic MemoryInfantInfluenza A virusInfluenza, HumanLymphocyte ActivationAntiviral AgentsCytokinesReceptors, Antigen, T-Cellanti-viral immunitycytomegalovirushuman immunologyimmunological memoryinfluenzalymphoid organsmucosal immunitytissue resident memory T cellsT lymphocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.