Evidence map›Paper›PMID 34852176›Full record

ReviewThe Journal of parasitology2021

REVIEW OF DNA VACCINE APPROACHES AGAINST THE PARASITE TOXOPLASMA GONDII.

Rosalie C Warner, Ryan C Chapman, Brianna N Davis, Paul H Davis

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Advances and Translational Challenges inVeterinary sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rosalie C WarnerDepartment of Biology, University of Nebraska at Omaha, Omaha, Nebraska, 68182.
Ryan C ChapmanDepartment of Biology, University of Nebraska at Omaha, Omaha, Nebraska, 68182.
Brianna N DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, Nebraska, 68182.
Paul H DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, Nebraska, 68182.ORCID 0000-0002-0526-3841
University of Nebraska at Omaha · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

Toxoplasma gondii is an apicomplexan parasite that affects both humans and livestock. Transmitted to humans through ingestion, it is the second-leading cause of foodborne illness-related death. Currently, there exists no approved vaccine for humans or most livestock against the parasite. DNA vaccines, a type of subunit vaccine which uses segments of the pathogen's DNA to generate immunity, have shown varying degrees of experimental efficacy against infection caused by the parasite. This review compiles DNA vaccine efforts against Toxoplasma gondii, segmenting the analysis by parasite antigen, as well as a review of concomitant adjuvant usage. No single antigenic group was consistently more effective within in vivo trials relative to others.

Indexed as

Adjuvants, ImmunologicAnimalsAntigens, ProtozoanHumansMicronemeProtozoan VaccinesToxoplasmaToxoplasmosisVaccines, DNAAdjuvants, ImmunologicAntigens, ProtozoanProtozoan VaccinesVaccines, DNAAdjuvantsAntigensDNA vaccinesToxoplasma gondii

Identifiers

PMID34852176
PMCPMC8638329
OpenAlexW3217566003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.