Evidence map›Paper›PMID 34852052›Full record

ArticleArquivos brasileiros de oftalmologia2021

Meibomian gland dysfunction and dry eye in keratoconus.

Roberto Damian Pacheco Pinto, Ricardo Yuji Abe, Flávia Cid Gomes, Alexandre Fattah Martini, Eduardo Buzolin Barbosa, Monica Alves

Open access · diamondAbstract readCase ReportsLetter
In one paragraph

Article in Arquivos brasileiros de oftalmologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Update on the Physiopathology of Keratoconus.Medical sciences (Basel, Switzerland) · 2026
    Review
  2. The relationship between correction modality and clinical signs and symptoms of dry eye and meibomian gland dysfunction in keratoconic patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Roberto Damian Pacheco PintoDiscipline of Ophthalmology and Otorhinolaryngology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.ORCID 0000-0002-5541-9672
Ricardo Yuji AbeHospital Oftalmológico de Brasília, Brasília, DF, Brazil.
Flávia Cid GomesDiscipline of Ophthalmology and Otorhinolaryngology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Alexandre Fattah MartiniDiscipline of Ophthalmology and Otorhinolaryngology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Eduardo Buzolin BarbosaDiscipline of Ophthalmology and Otorhinolaryngology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.ORCID 0000-0002-9240-2669
Monica AlvesDiscipline of Ophthalmology and Otorhinolaryngology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.ORCID 0000-0001-7940-0194
Hospital Oftalmologico de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this report is to describe a case of meibomian gland dysfunction associated with keratoconus and to examine the importance of treatment for evaporative dry eye in cases of corneal ectasia. A 45-year-old man diagnosed as having keratoconus complained of burning, tearing, itching, and red eye. He had a history of penetrating corneal transplantation and wearing rigid contact lenses. The meibography revealed a severe meibomian gland dropout and normal tear meniscus height in both eyes. Objective propaedeutic tests are important tools for dry eye diagnosis and proper evaluation of ocular surface and tear film. In older patients, the classic signs of atopic conjunctivitis are not always present, and the causes of chronic rubbing must be further investigated. Treatment of underlying chronic inflammation such as dry eye, meibomian gland dysfunction, and blepharitis might be important to prevent keratoconus progression and guarantee symptom relief.

Indexed as

Dry Eye SyndromesKeratoconusMeibomian Gland DysfunctionAgedHumansMaleMeibomian GlandsMiddle AgedTears

Identifiers

PMID34852052
PMCPMC11878407
OpenAlexW3214287186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.