ArticlePloS one2021
Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The association between atopic dermatitis and linear growth in children- a systematic review.European journal of pediatrics · 2024Pooled it
- Once-Daily Crisaborole Ointment, 2%, as a Long-Term Maintenance Treatment in Patients Aged ≥ 3 Months with Mild-to-Moderate Atopic Dermatitis: A 52-Week Clinical Study.American journal of clinical dermatology · 2023Trial
- Causal association between allergic diseases and short stature: a mendelian randomization study revealing the potential mediating role of inflammatory proteins.Jornal de pediatria · 2026Article
- Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes.Clinical reviews in allergy & immunology · 2026Review
- The age of eczema onset and multiple food allergies.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Parental Age and Childhood Allergy Risk.JAMA network open · 2026Article
- Decoding Early Clues: Immune Mechanisms, Prevention, Diagnosis, and Treatment of IgE-Mediated Peanut and Tree Nut Allergy in Children.Biomedicines · 2025Review
- Prevalence of food allergy and its association with atopic dermatitis in Iran: Results from the PERSIAN birth cohort.The journal of allergy and clinical immunology. Global · 2025Article
- Skin and oral intervention for food allergy prevention based on dual allergen exposure hypothesis.Clinical and experimental pediatrics · 2024Article
- Eczema in early childhood increases the risk of allergic multimorbidity.Clinical and translational allergy · 2024Article
- Insights into the clinical, immunologic, and genetic underpinnings of food allergy.Immunological reviews · 2024Review
- Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema.Nutrients · 2024Article
- Predictive modeling for cow's milk allergy remission by low-dose oral immunotherapy in young children.The World Allergy Organization journal · 2024Article
- Gastrointestinal Comorbidities Associated with Atopic Dermatitis-A Narrative Review.International journal of molecular sciences · 2024Review
- The relationship between umbilical cord blood IL-22 level and infantile eczema at 42 days.Frontiers in pediatrics · 2024Article
- Relationship between growth and food avoidance with food allergy at age 3 years: The Japan Environment and Children's Study (JECS).The World Allergy Organization journal · 2023Article
- Season of birth and atopic dermatitis in early infancy: results from the Japan Environment and Children's Study.BMC pediatrics · 2023Article
- Intake of allergenic foods at 1.5 years and 3 years of age in a general child population in Japan: a cross-sectional study.Environmental health and preventive medicine · 2023Article
- Food allergy testing in atopic dermatitis.JAAD international · 2022Article
- Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children's Study.Nutrients · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height, and body mass index (BMI), in addition to food allergy in a birth cohort among infants. This study design was a nationwide, multicenter, prospective birth cohort study-the Japan Environment and Children's Study (JECS). Generalized linear models were fitted for z scores of weight, height, BMI, and food allergy to evaluate the relationship between eczema and these outcomes for infants at age1, 2, and 3 years. Persistent eczema was negatively associated with height at the age of 2 years (estimated coefficient, -0.127; 95% confidence interval [CI], -0.16 to -0.095) and 3 years (-0.177; 95% CI, -0.214 to -0.139). The same tendency was also observed with weight and BMI. Early disease onset at younger than 1 year and persistent eczema had the strongest association with development of food allergy at age 3 years (OR, 11.794; 95% CI, 10.721-12.975). One phenotype of eczema with early-onset and persistent disease creates a risk of both physical growth impairment and development of food allergy. Infants who present with the early-onset and persistent type of eczema should be carefully evaluated daily for impaired physical growth and development of food allergy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.